Pau M Y, Pau K Y, Spies H G
Oregon Regional Primate Research Center, Beaverton 97006.
Physiol Behav. 1988;44(6):797-802. doi: 10.1016/0031-9384(88)90065-0.
The effects of a 36-amino acid peptide, neuropeptide Y (NPY), on feeding and drinking behaviors were studied in young and adult rabbits. Intraventricular injection of NPY to adult rabbits induced feeding and drinking in a dose-related manner. While the lowest doses tested (0.2 micrograms) was without effect, other doses (0.5 and 1 microgram) elicited feeding and drinking almost instantaneously. When 1, 5 and 10 microgram doses were injected into young rabbits, immediate increases in feeding and drinking were evident, but differences in the magnitude of responses among these dosages were significant only in water consumption. Unlike studies in rats, in these rabbits NPY elicited a more pronounced response in drinking than in feeding. The drinking response after NPY administration was not a consequence of food intake because it occurred in the absence of food. With ad lib feeding, the majority of enhanced food consumption was confined to the first 30-min after NPY injection; however, an increased motivation to eat was retained for at least 2 hr after NPY when food was withheld and then returned. These observations are consistent with specific stimulatory effects of NPY on food and water intake.
在幼年和成年兔中研究了一种36个氨基酸的肽——神经肽Y（NPY）对摄食和饮水行为的影响。向成年兔脑室内注射NPY会以剂量相关的方式诱导摄食和饮水。虽然所测试的最低剂量（0.2微克）没有效果，但其他剂量（0.5和1微克）几乎能立即引发摄食和饮水。当向幼年兔注射1、5和10微克剂量时，摄食和饮水立即明显增加，但这些剂量之间反应程度的差异仅在饮水量上有显著意义。与在大鼠中的研究不同，在这些兔子中，NPY引发的饮水反应比摄食反应更明显。NPY给药后的饮水反应不是食物摄入的结果，因为它在没有食物的情况下也会发生。在自由采食的情况下，大部分食物摄入量的增加局限于NPY注射后的前30分钟；然而，当食物被扣留然后再提供时，NPY注射后至少2小时内进食的动机仍然增加。这些观察结果与NPY对食物和水摄入的特定刺激作用一致。
