Sun Zih-Jie, Hsiao Hsuan-Jung, Cheng Hsiang-Ju, Chou Chieh-Ying, Lu Feng-Hwa, Yang Yi-Ching, Wu Jin-Shang, Chang Chih-Jen
Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Sheng Li Road, Tainan 70403, Taiwan.
Department of Family Medicine, National Cheng Kung University Hospital, Dou-Liou Branch, College of Medicine, National Cheng Kung University, No.345, Zhuangjing Rd., Douliu City, Yunlin 64043, Taiwan.
J Clin Med. 2020 Jun 2;9(6):1693. doi: 10.3390/jcm9061693.
Previous studies examining the association between kidney stone disease (KSD) and arterial stiffness have been limited. Both age and gender have been found to have an impact on KSD, but their influence on the relationship between KSD and increased arterial stiffness is unclear. This study included 6694 subjects from October 2006 to August 2009. The diagnosis of kidney stone was based on the results of ultrasonographic examination. Increased arterial stiffness was defined as right-sided brachial-ankle pulse wave velocity (baPWV) ≥ 14 m/s. Associations between KSD and increased arterial stiffness were analyzed using multiple logistic regression models. KSD was positively related to increased arterial stiffness in both male and female groups (males: odds ratio [OR], 1.306; 95% confidence interval [CI], 1.035-1.649; females: OR, 1.585; 95% CI, 1.038-2.419) after adjusting for confounding factors. Subgroup analysis by age group (<50 and ≥50 years) showed a significant positive relationship only in the groups ≥ 50 years for both genders (males: OR, 1.546; 95% CI, 1.111-2.151; females: OR, 1.783; 95% CI, 1.042-3.054), but not in the groups < 50 years. In conclusion, KSD is associated with a higher risk of increased arterial stiffness in individuals aged ≥ 50 years, but not in those aged < 50 years for both genders.
以往关于肾结石疾病（KSD）与动脉僵硬度之间关联的研究较为有限。年龄和性别均被发现对KSD有影响，但其对KSD与动脉僵硬度增加之间关系的影响尚不清楚。本研究纳入了2006年10月至2009年8月期间的6694名受试者。肾结石的诊断基于超声检查结果。动脉僵硬度增加定义为右侧臂踝脉搏波速度（baPWV）≥14米/秒。使用多重逻辑回归模型分析KSD与动脉僵硬度增加之间的关联。在调整混杂因素后，KSD在男性和女性组中均与动脉僵硬度增加呈正相关（男性：比值比[OR]，1.306；95%置信区间[CI]，1.035 - 1.649；女性：OR，1.585；95% CI，1.038 - 2.419）。按年龄组（<50岁和≥50岁）进行的亚组分析显示，仅在≥50岁的男女组中存在显著正相关（男性：OR，1.546；95% CI，1.111 - 2.151；女性：OR，1.783；95% CI，1.042 - 3.054），而在<50岁的组中未发现。总之，在≥50岁的个体中，KSD与动脉僵硬度增加的风险较高相关，但在<50岁的男女个体中并非如此。
