de Keijzer M H, Provoost A P, Molenaar J C
Department of Pediatric Surgery, Erasmus University, Rotterdam, The Netherlands.
Ren Physiol Biochem. 1988 Jan-Feb;11(1-2):103-8. doi: 10.1159/000173154.
The glomerular filtration rate (GFR), effective renal plasma flow (ERPF), systolic blood pressure (SBP) and urinary protein excretion (UpV) were determined in 12-week-old male rats of the spontaneously hypertensive Fawn-Hooded (FH) strain. These data were compared with those of either age-matched or weight-matched male, normotensive Wistar Albino Glaxo (WAG) rats. The GFR was significantly higher in FH rats than in both WAG control groups. In contrast, the ERPF did not differ between the FH and WAG rats. Thus, a higher filtration fraction was present in the FH rats. As no differences were found in the total number of glomeruli per kidney comparing FH and WAG rats, the high GFR was not due to an increase in the number of glomeruli. The SBP and the UpV were significantly higher in FH rats than in WAG rats. To our opinion, the arterial hypertension associated with glomerular hyperfiltration proteinuria suggests the presence of glomerular hypertension in FH rats.
在12周龄的自发性高血压鹿头罩（FH）品系雄性大鼠中测定了肾小球滤过率（GFR）、有效肾血浆流量（ERPF）、收缩压（SBP）和尿蛋白排泄量（UpV）。将这些数据与年龄匹配或体重匹配的正常血压雄性Wistar白化Glaxo（WAG）大鼠的数据进行比较。FH大鼠的GFR显著高于两个WAG对照组。相反，FH大鼠和WAG大鼠之间的ERPF没有差异。因此，FH大鼠存在较高的滤过分数。由于比较FH大鼠和WAG大鼠时，每只肾脏的肾小球总数没有差异，所以高GFR并非由于肾小球数量增加所致。FH大鼠的SBP和UpV显著高于WAG大鼠。我们认为，与肾小球高滤过蛋白尿相关的动脉高血压提示FH大鼠存在肾小球高血压。
