Israel R H, Ossip-Klein D J, Poe R H, Black P, Gerrity E, Greenblatt D W, Rathbun S, Celebic A
Department of Medicine, Highland Hospital.
Respiration. 1988;54(4):247-54. doi: 10.1159/000195532.
We studied the effect of smoking cessation on airway reactivity. We recruited cigarette smokers who were attempting to stop smoking. Entry criteria required each subject to be smoking at least 10 cigarettes each day and report a chronic cough. Exclusion criteria included significant airflow obstruction or the presence of any medical condition contraindicating challenge testing. Carbachol challenge was performed to assess airway reactivity according to a standardized method. Baseline measurements of forced expiratory volume in 1 s (FEV1), specific airway conductance (SGaw) and the provocative dose of carbachol causing a 35% reduction in SGaw (PD35), and a 20% reduction in FEV1 (PD20) were established on entry while each subject was still smoking. Thereafter, repeat measurements were performed after 2 and 6 months of smoking cessation. Adherence to smoking cessation was checked by self-report and verified by measurement of alveolar carbon monoxide levels at each session. Of the 34 subjects who gave consent, 13 relapsed prior to the 2nd month and an additional 8 relapsed before the 6th month. Thirteen of the 34 remained abstinent throughout the 6-month study. All 13 subjects had complete resolution of their cough. The difference in reactivity on entry to that at the 2nd and 6th month was not significant. We conclude that (1) the symptom of chronic cough resolved completely after 2 months of smoking cessation, and (2) airway reactivity remained unchanged at 2 and 6 months of smoking cessation.
我们研究了戒烟对气道反应性的影响。我们招募了正在尝试戒烟的吸烟者。纳入标准要求每位受试者每天至少吸食10支香烟且有慢性咳嗽症状。排除标准包括严重气流受限或存在任何禁忌激发试验的疾病状况。采用标准化方法进行卡巴胆碱激发试验以评估气道反应性。在每位受试者仍在吸烟时，于入组时测定1秒用力呼气量（FEV1）、比气道传导率（SGaw）以及使SGaw降低35%（PD35）和FEV1降低20%（PD20）的卡巴胆碱激发剂量作为基线测量值。此后，在戒烟2个月和6个月后进行重复测量。通过自我报告检查戒烟依从性，并在每次测量时通过测定肺泡一氧化碳水平进行验证。在34名同意参与研究的受试者中，13人在第2个月前复吸，另有8人在第6个月前复吸。34名受试者中有13人在整个6个月的研究期间保持戒烟状态。所有13名受试者的咳嗽症状均完全消失。入组时与第2个月和第6个月时的反应性差异不显著。我们得出结论：（1）戒烟2个月后慢性咳嗽症状完全消失，（2）戒烟2个月和6个月时气道反应性保持不变。
