Zhou Ye, Gao Huaqiang, Hua Haiying, Zhu Wenyan, Wang Zhiqing, Zhang Ye, Wu Shuang, Li Jin, Zhao Ying, Xue Lili
Department of Hematology, Affiliated Hospital of Jiangnan University, Wuxi 214041, China.
Department of Internal Medicine, Wuxi Maternity and Child Health Hospital, Wuxi 214002, China.
Ann Palliat Med. 2020 May;9(3):1109-1116. doi: 10.21037/apm-20-912.
Perianal infection is a common complication in patients with acute leukemia receiving chemotherapy. It usually manifests as a perianal mass, with redness/swelling, heat, and pain, and can affect physical and mental health in severe cases. The purpose of this study was to investigate the effectiveness of matrine sitz bath (MSB) in treating perianal infection after chemotherapy for acute leukemia.
A total of 216 acute leukemia patients with perianal infection that developed during chemotherapy were enrolled in this study and equally randomized into an MSB group and control group. The control group was treated with the conventional potassium permanganate sitz bath. After 14 days of treatment, the clinical efficacy and symptom/sign scores were compared between these 2 groups. The serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-10(IL-10), erythrocyte sedimentation rate (ESR), and prostaglandin E2 (PGE2) were detected by using enzyme-linked immunosorbent assay (ELISA).
The clinical efficacy of MSB group was significantly superior to that of the control group (P<0.05). The scores of anal pain, systemic symptoms, mass size, and mass texture were significantly decreased after treatment in both groups (P<0.05), and they were significantly lower in the MSB group than in the control group (P<0.05). After treatment, the serum levels of hs-CRP, TNF-α, ESR, and PGE2 in these 2 groups significantly dropped (P<0.05), and they were significantly lower in the MSB group than in the control group (P<0.05); IL-10 level significantly rose in both groups (P<0.05), and it was significantly higher in the MSB group than in the control group (P<0.05).
MSB is effective in treating perianal infection after chemotherapy for acute leukemia as it can effectively improve symptoms and signs and alleviate inflammatory reactions.
肛周感染是接受化疗的急性白血病患者常见的并发症。通常表现为肛周肿物，伴有红肿、发热和疼痛，严重时可影响身心健康。本研究旨在探讨苦参碱坐浴（MSB）治疗急性白血病化疗后肛周感染的疗效。
本研究共纳入216例化疗期间发生肛周感染的急性白血病患者，将其平均随机分为MSB组和对照组。对照组采用传统的高锰酸钾坐浴治疗。治疗14天后，比较两组的临床疗效及症状/体征评分。采用酶联免疫吸附测定（ELISA）法检测血清高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-10（IL-10）、红细胞沉降率（ESR）和前列腺素E2（PGE2）水平。
MSB组的临床疗效显著优于对照组（P<0.05）。两组治疗后肛门疼痛、全身症状、肿物大小和肿物质地评分均显著降低（P<0.05），且MSB组显著低于对照组（P<0.05）。治疗后，两组的hs-CRP、TNF-α、ESR和PGE2血清水平均显著下降（P<0.05），且MSB组显著低于对照组（P<0.05）；两组IL-10水平均显著升高（P<0.05），且MSB组显著高于对照组（P<0.05）。
MSB治疗急性白血病化疗后肛周感染有效，因为它能有效改善症状和体征，减轻炎症反应。
