College of Social Work, University of Kentucky, Lexington, Kentucky, USA
College of Social Work, University of Kentucky, Lexington, Kentucky, USA.
BMJ Open. 2020 Jun 3;10(6):e035517. doi: 10.1136/bmjopen-2019-035517.
Post-traumatic stress disorder (PTSD) is associated with an increased risk of dementia. Individual epidemiological studies have controlled for several confounders of the relationship between PTSD and increased dementia risk, yet particular risk factors underlying this relationship have not been determined. This systematic review protocol aims to identify risk and protective factors of dementia among adults with PTSD.
We will conduct an electronic search of the databases: PubMed, CINAHL, PsychINFO, The Cochrane Library, Scopus and ProQuest Dissertation and Theses Global. After screening the studies, quantitative synthesis will be performed, if possible. Otherwise, a narrative synthesis will be performed. We will include randomised controlled trials and other types of research evidence including longitudinal cohort studies. Strength of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluations method. Examples of variables that will be extracted are: year of PTSD diagnosis, comorbid conditions, health behaviours, pharmacological treatments and year of mild cognitive impairment or dementia diagnosis. We developed this systematic review protocol according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols 2015 statement.
The proposed study will not collect individual-level data and, therefore, does not require ethical approval. Results of this study will provide current evidence on risk and protective factors of dementia in adults with PTSD. Findings will be disseminated in peer-reviewed publications and conference presentations.
CRD42019128553.
创伤后应激障碍（PTSD）与痴呆风险增加有关。个别流行病学研究已经控制了 PTSD 与痴呆风险增加之间关系的几个混杂因素，但尚未确定这种关系的特定风险因素。本系统评价方案旨在确定 PTSD 成年人痴呆的风险和保护因素。
我们将对数据库进行电子检索：PubMed、CINAHL、PsychINFO、The Cochrane Library、Scopus 和 ProQuest Dissertation and Theses Global。筛选研究后，如果可能，将进行定量综合。否则，将进行叙述性综合。我们将包括随机对照试验和其他类型的研究证据，包括纵向队列研究。使用推荐的评估、制定和评估方法评估证据的强度。将提取的变量示例包括：PTSD 诊断年份、合并症、健康行为、药物治疗以及轻度认知障碍或痴呆诊断年份。我们根据 2015 年系统评价和荟萃分析报告的首选报告项目制定了本系统评价方案。
拟议的研究不会收集个体层面的数据，因此不需要伦理批准。本研究的结果将提供 PTSD 成年人痴呆风险和保护因素的最新证据。研究结果将在同行评议的出版物和会议演讲中发表。
PROSPERO 注册号：CRD42019128553。
