Yahya Husain, Sani Hadiza
Dermatology Unit, Department of Medicine, Barau Dikko Teaching Hospital, Kaduna State University, Kaduna, Nigeria.
Ann Afr Med. 2020 Apr-Jun;19(2):150-152. doi: 10.4103/aam.aam_37_19.
Neurofibromatosis type 1 is the most common inherited nervous system disorder affecting 1 in 3500 live births. Cutaneous neurofibromas, the most characteristic feature of the disease, begin to appear in adolescence and continue throughout adulthood. Although neurofibromas have been noted to increase in size or number during pregnancy, there have been very few reports of eruption of a large number of lesions during this period. We report a case of a 24-year-old Nigerian woman of 32-week gestation who presented with a history of sudden eruption of neurofibromas during the current pregnancy and the previous one 3 years earlier. We discuss how hormones and growth factors contribute to the increase in numbers of neurofibromas during pregnancy, which is occasionally severe, as in our case, and the complications which may arise in the mother and fetus.
1型神经纤维瘤病是最常见的遗传性神经系统疾病，每3500例活产中就有1例受影响。皮肤神经纤维瘤是该疾病最具特征性的表现，在青春期开始出现，并持续至成年期。虽然神经纤维瘤在孕期会增大或增多，但在此期间大量皮疹发作的报道很少。我们报告一例24岁尼日利亚女性，孕32周，有本次孕期及3年前前次孕期神经纤维瘤突然发作的病史。我们讨论了激素和生长因子如何导致孕期神经纤维瘤数量增加，在我们的病例中偶尔会很严重，以及母亲和胎儿可能出现的并发症。
