Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
Faculdade de Ciencias da Saude da Universidade da Beira Interior, Covilha, Portugal.
Breast J. 2020 Jun;26(6):1148-1155. doi: 10.1111/tbj.13857. Epub 2020 Jun 4.
The designation of noninvasive lobular neoplasia applies to atypical epithelial proliferations composed of noncohesive cells secondary to loss or functional alteration of E-cadherin-mediated cell adhesion. The morphologic spectrum of noninvasive lobular neoplasia encompasses atypical lobular hyperplasia (ALH) and classic lobular carcinoma in situ (classic LCIS) and two LCIS variants, namely florid LCIS (F-LCIS) and pleomorphic LCIS (P-LCIS), as defined in the World Health Organization (WHO) Classification of Tumors of the Breast 5th ed. Herein, we review the morphologic, immunohistochemical, and molecular features of noninvasive lobular neoplasia, with special emphasis on F-LCIS and P-LCIS. We also review imaging features, management at core needle biopsy, upgrade rates at surgical excision, and clinical management dilemmas.
非浸润性小叶肿瘤的定义适用于非黏附性细胞的上皮细胞非典型性增生，这些细胞继发于 E-钙黏蛋白介导的细胞黏附丧失或功能改变。非浸润性小叶肿瘤的形态学谱包括不典型小叶增生（ALH）和经典小叶原位癌（经典 LCIS）以及两种 LCIS 变体，即弥漫性 LCIS（F-LCIS）和多形性 LCIS（P-LCIS），这在世界卫生组织（WHO）第 5 版《乳腺肿瘤分类》中有定义。本文中，我们将综述非浸润性小叶肿瘤的形态学、免疫组织化学和分子特征，特别强调 F-LCIS 和 P-LCIS。我们还将综述影像学特征、在核心针活检中的处理、在手术切除中的升级率以及临床管理困境。
