Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, PR China; Queen Mary School, Medical Department, Nanchang University, Nanchang, Jiangxi 330006, PR China.
Department of Histology and Embryology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, PR China; Jiangxi Key Laboratory of Experimental Animals, Nanchang University, Nanchang, Jiangxi 330006, PR China.
Biomed Pharmacother. 2020 Aug;128:110329. doi: 10.1016/j.biopha.2020.110329. Epub 2020 Jun 2.
Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies in the world with high relapse and mortality rates. Although oxaliplatin (OXA), a platinum-based anticancer drug, is widely used in CRC treatment, the resulting chemoresistance dramatically attenuates the drug efficacy and increases the failure rate of this therapy. Thus, the study on OXA-induced chemoresistance is extremely urgent. In recent years, emerging evidence has shown that lncRNAs play irreplaceable roles in drug resistance. However, we only have a limited knowledge of the lncRNAs that are closely related to oxaliplatin resistance in CRC. In present study, we identify and characterize these lncRNAs, including their functions, underlying mechanisms and possible applications.
结直肠癌（CRC）是世界上最常见的恶性肿瘤之一，其复发率和死亡率均较高。尽管奥沙利铂（OXA）是一种广泛应用于 CRC 治疗的基于铂的抗癌药物，但由此产生的化疗耐药性极大地降低了药物疗效并增加了该治疗的失败率。因此，研究 OXA 诱导的化疗耐药性极为紧迫。近年来，新出现的证据表明 lncRNAs 在耐药性中发挥着不可替代的作用。然而，我们对与 CRC 中奥沙利铂耐药密切相关的 lncRNAs 知之甚少。在本研究中，我们鉴定并表征了这些 lncRNAs，包括它们的功能、潜在机制和可能的应用。
