Hanpanich Orakan, Maruyama Atsushi
Department of Life Science and Technology, Tokyo Institute of Technology, Nagatsuta 4259 B-57, Yokohama, 226-8501, Japan.
Department of Life Science and Technology, Tokyo Institute of Technology, Nagatsuta 4259 B-57, Yokohama, 226-8501, Japan.
Biomaterials. 2020 Sep;254:120150. doi: 10.1016/j.biomaterials.2020.120150. Epub 2020 May 27.
Biological macromolecules must fold into native structures to gain functional activities. In living cells, proteins called molecular chaperones mediate productive folding by preventing undesired interactions and aggregation and by facilitating refolding of misfolded macromolecules into their bioactive forms. Inspired by natural molecular chaperones, artificial chaperones that mimic some features of their biological counterparts have been designed. This review describes recent progress in the development of artificial chaperones and their promising applications in enhancing macromolecular assembly of proteins, polypeptides, and nucleic acids.
生物大分子必须折叠成天然结构才能获得功能活性。在活细胞中，称为分子伴侣的蛋白质通过防止不期望的相互作用和聚集以及促进错误折叠的大分子重新折叠成其生物活性形式来介导有效的折叠。受天然分子伴侣的启发，人们设计了模仿其生物学对应物某些特征的人工伴侣。本文综述了人工伴侣开发的最新进展及其在增强蛋白质、多肽和核酸大分子组装方面的应用前景。
