Division of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Province Guangdong, People's Republic of China.
Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Province Guangdong, People's Republic of China.
BMC Cancer. 2020 Jun 5;20(1):520. doi: 10.1186/s12885-020-06972-5.
According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Due to its rarity, no study investigating the impact of different subtypes on the clinical features, radiologic findings and prognosis characteristics of ASC has been reported.
Sixty eight patients who underwent surgical resection for lung adenosquamous carcinoma in our institute between January 2006 and March 2017 were retrospectively reviewed. Data regarding the clinical features, radiologic findings and prognosis characteristics were collected.
Thirty nine patients of the study cohort were with AC-predominant ASC and 29 with SCC-predominant ASC. There was no significant difference between the two subgroups in age, gender, smoking history, serum carcinoembryonic antigen (CEA) level and T,N classification. Air bronchogram was found more frequently in AC-predominant ASC than in SCC-predominant ASC (P = 0.046). Multivariate analysis identified pathological subtype (P = 0.022) and CT findings of peripheral location (P = 0.009) to be independent prognostic factors.
AC-predominant ASC were more commonly presented with air bronchogram, and were with a better prognosis than SCC-predominant ASC.
根据腺鳞癌（ASC）中腺体和鳞状病理成分的比例，可将其分为腺癌（AC）和鳞状细胞癌（SCC）为主型。由于其罕见性，尚无研究探讨不同亚型对 ASC 的临床特征、影像学表现和预后特征的影响。
回顾性分析 2006 年 1 月至 2017 年 3 月我院行手术切除的 68 例肺腺鳞癌患者的临床资料，收集患者的临床特征、影像学表现和预后特征。
研究队列中有 39 例患者为 AC 为主型 ASC，29 例患者为 SCC 为主型 ASC。两组患者在年龄、性别、吸烟史、血清癌胚抗原（CEA）水平和 T、N 分期方面无显著差异。AC 为主型 ASC 中空气支气管征较 SCC 为主型 ASC 更为常见（P=0.046）。多因素分析发现，病理亚型（P=0.022）和 CT 表现为外周位置（P=0.009）是独立的预后因素。
AC 为主型 ASC 更常表现为空气支气管征，且预后优于 SCC 为主型 ASC。
