Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
BMC Psychiatry. 2020 Jun 5;20(1):282. doi: 10.1186/s12888-020-02663-4.
Systemic inflammation is emerging as an important factor in the etiology of psychiatric disorders such as depression and anxiety. Therefore, the inflammatory potential of the diet may also be an etiological factor for these conditions, and this may be estimated by calculating the dietary inflammatory index (DII®) score. We aimed to investigate the association between DII score and incidence of depression and anxiety among a representative sample in northeastern Iran.
This cross-sectional study undertook in a sub-sample of 7083 adults aged 35 to 65 years recruited as part of Mashhad stroke and heart atherosclerotic disorder (MASHAD) cohort study population, and after excluding subjects with incomplete data. All participants completed the Beck Anxiety Inventory (BAI), the Beck Depression Inventory II (BDI-II), and a validated 65-item food frequency questionnaire (FFQ). Logistic regression was used to evaluate the association between DII score and depression/anxiety score.
Of the study participants, 37.1% (n = 2631) were found to have mild to severe depression, and 50.5% (n = 3580) were affected by mild to severe anxiety. After adjusting for confounding factors, in women, the third (OR: 1.41, 95% CI: 1.06-1.88, p-values< 0.05) and fourth quartiles (OR: 1.37, 95% CI: 1.03-1.83, p-values< 0.05) of DII score were associated with increased risk of a high depression score compared to the first quartile of DII score.
There was a significant association between DII score and severe depression among women but not men in this Iranian population. In order to confirm the association between DII food score, depression, and anxiety, further research is required in different populations, and perhaps an intervention study.
系统性炎症正在成为抑郁和焦虑等精神疾病病因学的一个重要因素。因此，饮食的炎症潜能也可能是这些疾病的一个病因学因素，而这可以通过计算饮食炎症指数（DII®）评分来估计。我们旨在调查伊朗东北部代表性样本中 DII 评分与抑郁和焦虑发生率之间的关联。
本横断面研究纳入了作为马什哈德中风和心脏动脉粥样硬化疾病（MASHAD）队列研究人群的一部分招募的 7083 名年龄在 35 至 65 岁之间的成年人的亚样本，并且排除了数据不完整的受试者。所有参与者完成了贝克焦虑量表（BAI）、贝克抑郁量表 II（BDI-II）和经过验证的 65 项食物频率问卷（FFQ）。使用逻辑回归评估 DII 评分与抑郁/焦虑评分之间的关联。
在研究参与者中，37.1%（n=2631）被发现患有轻度至重度抑郁，50.5%（n=3580）患有轻度至重度焦虑。在调整混杂因素后，在女性中，与 DII 评分第一四分位相比，第三四分位（OR：1.41，95%CI：1.06-1.88，p 值<0.05）和第四四分位（OR：1.37，95%CI：1.03-1.83，p 值<0.05）的 DII 评分与较高的高抑郁评分风险相关。
在伊朗人群中，DII 评分与女性重度抑郁之间存在显著关联，但与男性无关。为了确认 DII 食物评分、抑郁和焦虑之间的关联，需要在不同人群中进行进一步的研究，也许还需要进行干预研究。
