Ann Ital Chir. 2021;92:242-248.
In this study, we aimed to determine the clinical value and prognostic significance of the Neutrophil / Lymphocyte Ratio in patients undergoing curative surgery due to esophageal cancer.
Patients who underwent curative resection for esophageal cancer between 2015-2019 were included in the study. Two groups, Group1 (low NLR) and Group2 (high NLR), were created. Demographic and clinical features, intraoperative and postoperative results, tumor characteristics and mean survival were compared in the groups.
A total of 48 patients participated in our study. Group 1 consisted of 18 patients and Group 2 consisted of 30 patients. Male sex was dominant in both groups (66.7% vs 73.3%, p. 0.431). Preoperative CEA was higher in Group 2 (3.97 vs 9.57, p. 0.032). Tumor diameter was larger in Group2 (3.33 vs 5.40 cm, p. 0.000). Adenocarcinoma was higher in Group 2 (33% vs 53.3%, p. 0.047), while squamous cell carcinoma was higher in Group 1 (66.7% vs 33.3%, p. 0.047). Lymph node positivity was higher in Group 2 (66.7% vs 93.3%, p. 0.024). The anastomosis leak was higher in Group 2 (0% vs 20%, p. 0.048). Postoperative hospital stay was longer in Group 2 (13.27 vs 23.9 days, p. 0.009). 90-day readmission was higher in Group1 (33.3% vs 3.3%, p. 0.008). Survival duration was shorter in Group 2 (29 vs 15 months, p. 0.005).
This study revealed that preoperative high NLR was associated with poor survival, along with greater tumor diameter, increased lymph node metastasis rate, and increased anastomosis leakage in patients with esophageal cancer. These results suggest that modifying inflammatory responses and modulating the immune system may improve survival outcomes in patients with esophageal cancer.
Esophagus cancer, Neutrophil/lymphocyte ratio, Preoperative neutrophil/lymphocyte ratio, Prognosis.
本研究旨在探讨中性粒细胞/淋巴细胞比值（NLR）在接受根治性手术治疗的食管癌患者中的临床价值和预后意义。
纳入 2015 年至 2019 年间接受根治性食管癌切除术的患者进行研究。将患者分为两组：NLR 较低的 Group1（低 NLR 组）和 NLR 较高的 Group2（高 NLR 组）。比较两组患者的人口统计学和临床特征、术中及术后结果、肿瘤特征和平均生存时间。
共纳入 48 例患者。Group1 包括 18 例患者，Group2 包括 30 例患者。两组均以男性为主（66.7%比 73.3%，p.0.431）。Group2 的术前 CEA 水平较高（3.97 比 9.57，p.0.032）。Group2 的肿瘤直径较大（3.33 比 5.40cm，p.0.000）。Group2 的腺癌比例较高（33%比 53.3%，p.0.047），而 Group1 的鳞状细胞癌比例较高（66.7%比 33.3%，p.0.047）。Group2 的淋巴结阳性率较高（66.7%比 93.3%，p.0.024）。Group2 的吻合口漏发生率较高（0%比 20%，p.0.048）。Group2 的术后住院时间较长（13.27 比 23.9 天，p.0.009）。Group1 的 90 天再入院率较高（33.3%比 3.3%，p.0.008）。Group2 的生存时间较短（29 比 15 个月，p.0.005）。
本研究表明，术前 NLR 较高与食管癌患者的生存不良相关，且与肿瘤直径较大、淋巴结转移率增加和吻合口漏发生率增加相关。这些结果提示，调节炎症反应和免疫系统可能改善食管癌患者的生存结局。
食管癌、中性粒细胞/淋巴细胞比值、术前中性粒细胞/淋巴细胞比值、预后。
