Kaufman Matthew E, Miller Devin T, Ullah Asad, White Joseph, Singh Gurmukh, Kolhe Ravindra, Williams Hadyn, Mittal Pardeep, Parikh Jigarkumar, Terris Martha K
Section of Urologic Oncology, Augusta University Medical Center, Augusta, GA.
Section of Gynecologic Oncology, Augusta University Medical Center, Augusta, GA.
Urology. 2021 May;151:182-187. doi: 10.1016/j.urology.2020.05.032. Epub 2020 Jun 3.
To determine if adenocarcinoma of the Skene's glands in women, which has a histological and immunohistochemical appearance similar to prostate cancer, can be evaluated and managed with the same tools we use for prostate cancer.
Serum prostate-specific antigen kinetics, 3D multiparametric (MP) magnetic resonance imaging (MRI), fluciclovine F-18 positron emission tomography (PET), and androgen deprivation therapy (ADT) were employed in a case of Skene's gland adenocarcinoma.
The 3D MP MRI clarified the anatomy of the primary lesion and fluciclovine F-18 PET significantly improved our ability to stage the tumor prompting pelvic lymph node dissection that may have otherwise not been performed. ADT resulted in a significant impact on prostate-specific antigen kinetics despite the patient having a testosterone level in the normal range for a postmenopausal woman.
Despite the rarity of Skene's gland adenocarcinoma, we can employ many of the tools at our disposal for the evaluation and management of prostate cancer to benefit the women found to have this malignancy.
确定女性斯基恩氏腺腺癌（其组织学和免疫组化表现与前列腺癌相似）是否可用我们用于前列腺癌的相同工具进行评估和治疗。
对一例斯基恩氏腺腺癌患者采用血清前列腺特异性抗原动力学、三维多参数（MP）磁共振成像（MRI）、氟代脱氧胸苷F-18正电子发射断层扫描（PET）及雄激素剥夺治疗（ADT）。
三维MP MRI明确了原发灶的解剖结构，氟代脱氧胸苷F-18 PET显著提高了我们对肿瘤分期的能力，促使进行盆腔淋巴结清扫，否则可能不会进行该操作。尽管患者的睾酮水平处于绝经后女性的正常范围内，但ADT对前列腺特异性抗原动力学产生了显著影响。
尽管斯基恩氏腺腺癌罕见，但我们可以使用许多现有的用于前列腺癌评估和治疗的工具，以使患有这种恶性肿瘤的女性受益。
