Epigenetics and Cellular Senescence Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Epigenetics and Cellular Senescence Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
Trends Cell Biol. 2020 Aug;30(8):628-639. doi: 10.1016/j.tcb.2020.05.003. Epub 2020 Jun 3.
Intercellular communication refers to the different ways through which cells communicate with each other and transfer a variety of messages. These communication methods involve a number of different processes that occur individually or simultaneously, which change depending on the physiological or pathological context. The best characterized means of intercellular communication is the release of soluble factors that affect the function of neighboring cells. However, there are many other ways by which cells can communicate with each other. Here, we review the different means of intercellular communication including soluble factors in the context of senescence, ageing, and age-related diseases.
细胞间通讯是指细胞之间相互交流并传递各种信息的不同方式。这些通讯方式涉及许多不同的过程，这些过程单独或同时发生，具体取决于生理或病理环境。细胞间通讯的最佳特征方式是释放可溶性因子，这些因子会影响邻近细胞的功能。但是，细胞之间还有许多其他的通讯方式。在这里，我们综述了包括衰老、老化和与年龄相关的疾病背景下的可溶性因子在内的不同细胞间通讯方式。
