Health Management Institute, Xinjiang Medical University, China; Public Health School of Xinjiang Medical University, China.
Department of Microrepair and Reconstruction, the First Affiliated Hospital of Xinjiang Medical University, China.
Clin Res Hepatol Gastroenterol. 2020 Nov;44(6):894-904. doi: 10.1016/j.clinre.2020.02.005. Epub 2020 Jun 3.
To investigate the association of polymorphisms of Pro12Ala of peroxisome proliferator-activated receptor gamma (PPARγ) gene with clinical and biochemical parameters in Uygur Chinese population with non-alcoholic fatty liver (NAFLD) METHODS: In this case-control study, we recruited 467 NAFLD cases and 524 controls. Examination of abdominal ultrasound, clinical and biochemical profiles, as well as polymerase chain reaction-restriction fragment length polymorphisms of Pro12Ala of PPARγ gene were performed. The association of PPARγ gene Pro12Ala variants with clinical and biochemical parameters was analyzed.
There was no statistically significant difference between NAFLD and control groups in the frequencies of genotypic and allele distribution (P>0.05), while significantly difference of genotypic (P=0.032) and allele (P=0.015) distribution was found between NAFLD and control groups in the obese. Using logistics multivariate regression analysis by adjusting age, sex, body mass index, diabetes, hyperuricemia and dyslipidemia, both Pro12Ala and Ala12Ala polymorphisms were not associated with the presence of NAFLD. However, above two polymorphisms were found to be related to NAFLD in obesity group (odds ratio=0.442, P=0.031 and odds ratio=0.039, P=0.010, respectively) CONCLUSION: In Uygur Chinese population, PPARr gene Ala variants reduce the risk of NAFLD in obese individuals.
探讨过氧化物酶体增殖物激活受体γ（PPARγ）基因 Pro12Ala 多态性与维吾尔族非酒精性脂肪性肝病（NAFLD）患者临床和生化参数的关系。
在这项病例对照研究中，我们招募了 467 例 NAFLD 患者和 524 例对照。对腹部超声、临床和生化特征以及 PPARγ基因 Pro12Ala 多聚酶链反应-限制性片段长度多态性进行了检测。分析了 PPARγ基因 Pro12Ala 变异与临床和生化参数的关系。
在非酒精性脂肪肝组和对照组之间，基因型和等位基因分布频率无统计学差异（P>0.05），而在肥胖组中，基因型（P=0.032）和等位基因（P=0.015）分布存在显著差异。采用多元logistic 回归分析，校正年龄、性别、体重指数、糖尿病、高尿酸血症和血脂异常，Pro12Ala 和 Ala12Ala 多态性均与 NAFLD 的发生无关。然而，上述两种多态性在肥胖组中与 NAFLD 相关（比值比=0.442，P=0.031；比值比=0.039，P=0.010）。
在维吾尔族人群中，PPARγ基因 Ala 变异可降低肥胖个体患 NAFLD 的风险。
