钙信号和脂质转移在 ER-PM 接触位点“二人转”，协调细胞迁移。

Ca signaling and lipid transfer 'pas a deux' at ER-PM contact sites orchestrate cell migration.

机构信息

Department of Physiology and Biophysics, Ca(2+) Signaling Group, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar.

出版信息

Cell Calcium. 2020 Jul;89:102226. doi: 10.1016/j.ceca.2020.102226. Epub 2020 Jun 1.

DOI:10.1016/j.ceca.2020.102226

PMID:32505782

Abstract

Contact sites between the endoplasmic reticulum (ER) and plasma membrane (PM) regulate both non-vesicular lipid transfer as well as Ca signaling with multiple interactions between the two pathways. Here I discuss recent findings that offer exciting insights into the role of store-operated Ca entry (SOCE), Oxysterol-binding protein (OSBP)-related proteins ORP3, Arf5 and the Arf GEF IQSec1 in this crosstalk and how they regulate cell migration and focal adhesion disassembly.

摘要

内质网（ER）和质膜（PM）之间的接触位点调节非囊泡脂质转移以及 Ca 信号转导，两条途径之间存在多种相互作用。在这里，我将讨论最近的发现，这些发现为了解储存操作 Ca 内流（SOCE）、氧化固醇结合蛋白（OSBP）相关蛋白 ORP3、Arf5 和 Arf GEF IQSec1 在这种串扰中的作用以及它们如何调节细胞迁移和焦点粘连解体提供了令人兴奋的见解。