Velleja Research, Milan, Italy -
ATS Milan, Milan, Italy.
Minerva Pediatr (Torino). 2021 Jun;73(3):222-229. doi: 10.23736/S2724-5276.20.05925-3. Epub 2020 Jun 4.
For healthy children, attending communities such as nurseries, kindergartens or schools, exposes them to the risk of acute gastroenteritis (AGE) and/or upper respiratory tract infections (URTIs). We therefore evaluated whether the use of a well-documented probiotic formula could act as prophylaxis for AGE and URTIs, reducing the risk of occurrence.
In a randomized study, we tested a probiotic mixture containing Bifidobacterium animalis subspecies lactis BB-12 and Enterococcus faecium L3 on 94 healthy children, comparing the incidence and duration of episodes of AGE and the incidence of URTIs to those of a control group of 109 healthy, untreated subjects. In a subgroup consisting of 34 healthy, treated children, we also evaluated salivary IgA levels.
The use of the probiotic formula significantly reduced the incidence and duration of episodes of AGE by 82% and 45%, respectively, and the incidence and duration of episodes of URTIs by 84% and 50%. Salivary IgA levels significantly increased three-fold after 90 days of probiotic treatment. The probiotic formula was well tolerated and no side effects occurred.
According to our results, use of the probiotic strains BB-12 and L3 statistically reduced the risk of AGE and URTIs in healthy children and increased levels of salivary IgA.
对于健康的儿童来说，上托儿所、幼儿园或学校等社区会使他们面临急性肠胃炎（AGE）和/或上呼吸道感染（URTI）的风险。因此，我们评估了使用一种有充分文献记录的益生菌配方是否可以作为 AGE 和 URTI 的预防措施，降低发病风险。
在一项随机研究中，我们测试了一种含有双歧杆菌亚种 lactis BB-12 和粪肠球菌 L3 的益生菌混合物，将其应用于 94 名健康儿童，将其与 109 名未经治疗的健康对照组相比，评估 AGE 发作的发生率和持续时间以及 URTI 的发生率。在由 34 名健康、接受治疗的儿童组成的亚组中，我们还评估了唾液 IgA 水平。
使用益生菌配方可分别将 AGE 发作的发生率和持续时间降低 82%和 45%，将 URTI 发作的发生率和持续时间降低 84%和 50%。在接受益生菌治疗 90 天后，唾液 IgA 水平显著增加了三倍。益生菌配方耐受性良好，无不良反应发生。
根据我们的结果，使用益生菌菌株 BB-12 和 L3 可显著降低健康儿童 AGE 和 URTI 的发病风险，并提高唾液 IgA 水平。
