菠萝汁对人体塞来昔布和孟鲁司特药代动力学的影响。
Effect of pineapple juice on the pharmacokinetics of celecoxib and montelukast in humans.
机构信息
Department of Pharmaceutics, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
Department of Clinical & Hospital Pharmacy, Faculty of Pharmacy, Taibah University, AL-Madinah AL-Munawarah, Kingdom of Saudi Arabia.
出版信息
Ther Deliv. 2020 May;11(5):301-311. doi: 10.4155/tde-2020-0020. Epub 2020 Jun 8.
To study the influence of pineapple juice on the pharmacokinetics of celecoxib and montelukast in humans. The research comprised two separate arms. Each arm was randomized, two-crossover periods separated by a 2-week washout period. Subjects received a single dose of celecoxib or montelukast after pretreatment with either water or pineapple juice for 4 days before the study beginning. Pineapple juice enhanced the systemic exposure of both drugs without any noticeable adverse effects. For celecoxib, C and AUC were increased significantly by 40 and 60%, respectively. Cl/F was decreased by 45% without affecting its t. For montelukast, C and AUC were significantly increased by 21 and 48%, respectively, along with 25% decrease in clearance and 13% increase in t.
研究菠萝汁对人体塞来昔布和孟鲁司特药代动力学的影响。该研究包括两个独立的部分。每个部分都是随机的，两个交叉期之间有两周的洗脱期。在研究开始前，受试者连续 4 天分别用清水或菠萝汁预处理后，单次服用塞来昔布或孟鲁司特。菠萝汁可增强两种药物的全身暴露，无明显不良反应。对于塞来昔布，C 和 AUC 分别显著增加 40%和 60%。CL/F 下降 45%，但 t 不变。对于孟鲁司特，C 和 AUC 分别显著增加 21%和 48%，清除率下降 25%，t 增加 13%。
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