Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Acta Neurol Belg. 2021 Oct;121(5):1247-1250. doi: 10.1007/s13760-020-01374-7. Epub 2020 Jun 7.
Patients with refractory epilepsy can suffer from psychological and physical problems. Epilepsy can also be associated with menstruation abnormalities in women. In this paper, we aim to survey women with focal refractory epilepsy who also suffer from menstrual abnormalities. This cross-sectional study was performed in 2018 in Tertiary Epilepsy Center in Kashani Hospital, Isfahan, Iran and Milad hospital, Isfahan, Iran. A total number of 381 patients diagnosed with refractory epilepsy joined the study based on an inclusion and exclusion criteria. Clinical characteristics of epilepsy, menstrual issues and brain MRI findings were assessed. Among 381 women with refractory epilepsy, 250 had refractory focal epilepsy (65.61%), and the others (34.39%) had generalized refractory epilepsy. 132 patients out of 381 had menstrual abnormalities (34.65%). Among 132 women with coexisting refractory epilepsy and menstrual abnormalities, 86 (65.15%) were diagnosed with refractory focal epilepsy, and 46 (34.86%) had generalized refractory epilepsy (p value = 0.041). Oligomenorrhea-hypomenorrhea was the most common type of menstrual abnormality in women with refractory epilepsy seen in 83 (62.87%) (p value = 0.039). The most common brain MRI pathology in women with refractory focal epilepsy was mesial temporal sclerosis (MTS) (39.20%, p = 0.00). We report that almost one-third of women with refractory epilepsy suffer from menstrual disorders, and the most common disorder was Oligomenorrhea-hypomenorrhea, and the most common brain pathology was MTS. It has also been a hypothesis that reproductive dysfunctions are connected to temporal lobe malfunctions, and more specific studies are required in this issue.
患有难治性癫痫的患者可能会出现心理和身体问题。癫痫也可能与女性的月经异常有关。在本文中，我们旨在调查患有局灶性难治性癫痫且伴有月经异常的女性。这项横断面研究于 2018 年在伊朗伊斯法罕 Kashani 医院和 Milad 医院的三级癫痫中心进行。根据纳入和排除标准，共有 381 名被诊断为难治性癫痫的患者参加了研究。评估了癫痫的临床特征、月经问题和脑 MRI 结果。在 381 名患有难治性癫痫的女性中，250 名患有难治性局灶性癫痫（65.61%），其余（34.39%）患有全身性难治性癫痫。381 名女性中有 132 名出现月经异常（34.65%）。在 132 名同时患有难治性癫痫和月经异常的女性中，86 名（65.15%）被诊断为难治性局灶性癫痫，46 名（34.86%）患有全身性难治性癫痫（p 值=0.041）。在难治性癫痫女性中，最常见的月经异常类型是少经或闭经，有 83 名（62.87%）（p 值=0.039）。患有难治性局灶性癫痫的女性最常见的脑 MRI 病理学是内侧颞叶硬化症（MTS）（39.20%，p=0.00）。我们报告说，近三分之一的难治性癫痫女性患有月经紊乱，最常见的紊乱是少经或闭经，最常见的脑病理学是 MTS。有人假设生殖功能障碍与颞叶功能障碍有关，需要对此问题进行更具体的研究。
