Marian Newton, PhD, PMHNP-BC, PMHCNS, ANEF, Eleanor Wade Custer School of Nursing, Shenandoah University, Winchester, VA, USA.
David W. Newton, BS Pharm, PhD, FAPhA, Pharmacy Professor Emeritus, Shenandoah University, Winchester, VA, USA.
J Am Psychiatr Nurses Assoc. 2020 Sep/Oct;26(5):447-457. doi: 10.1177/1078390320929410. Epub 2020 Jun 6.
This article presents proven, promising, and potential therapeutic uses for cannabidiol (CBD) in the treatment of psychiatric and neurologic conditions and diseases. It presents popular, but scientifically unproven health and therapeutic claims of CBD supporting the beneficial homeostatic effects of the intrinsic or endogenous cannabinoid system. It includes a review of cannabinoid pharmacology; it compares properties and the legal status of CBD and THC (delta 9-tetrahydrocannabinol) as well as the hemp and marijuana varieties of , and it reviews the historic 2018 U.S. Food and Drug Administration approval of Epidiolex, an oral solution of cannabidiol for two rare treatment-resistant childhood epilepsies, as the first -derived drug. We reviewed literature on cannabidiol, CBD, the endocannabinoid neuropharmacology system, and hemp and marijuana varieties of . The proven and promising medical uses and deficiencies of unproven health claims for CBD, legal implications for -derived drugs, and comparisons of CBD and THC and hemp and marijuana are summarized objectively with pertinent references. CBD and CBD and THC combinations have potential to provide safe, effective therapy for several psychiatric and neurologic conditions and diseases. However, such achievement will require a uniform standard of CBD purity and strength, and corroboration from adequately large and rigorously controlled clinical research studies.
本文介绍了大麻二酚（CBD）在治疗精神和神经疾病方面的已证实、有前景和潜在的治疗用途。它介绍了 CBD 的一些流行的、但未经科学证实的健康和治疗功效，这些功效支持内源性大麻素系统的有益的体内平衡作用。本文包括对大麻素药理学的回顾；比较了 CBD 和四氢大麻酚（Δ9-四氢大麻酚）以及大麻品种和大麻品种的特性和法律地位，并回顾了 2018 年美国食品和药物管理局批准的大麻二醇口服溶液，用于治疗两种罕见的耐药性儿童癫痫，这是第一种衍生药物。我们回顾了有关大麻二酚、CBD、内源性大麻素神经药理学系统以及大麻和大麻品种的文献。本文客观地总结了 CBD 已证实和有前景的医疗用途以及未经证实的健康功效的不足之处、衍生药物的法律含义，以及 CBD 和四氢大麻酚以及大麻和大麻的比较，并附有相关参考文献。CBD 和 CBD 与四氢大麻酚的组合有可能为几种精神和神经疾病提供安全、有效的治疗方法。然而，要实现这一目标，需要 CBD 纯度和效力的统一标准，并需要得到足够大和严格控制的临床研究的证实。
