Pereira Treville, Surve Ridima, Shetty Subraj, Gotmare Swati
Department of Oral and Maxillofacial Pathology and Microbiology, D. Y. Patil Deemed to be University School of Dentistry, Navi Mumbai, Maharashtra, India.
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):106-112. doi: 10.4103/jomfp.JOMFP_234_19. Epub 2020 May 8.
Oral submucous fibrosis (OSF) is a precancerous condition predominantly seen in people of Asian descent. About 7%-12% of OSF patients develop oral squamous cell carcinoma. Morphological features of OSF, especially fibrosis, suggest a possibility of hypoxic environment in diseased tissues. Neovascularization and increased glycolysis, represent adaptations to a hypoxic microenvironment that are correlated with tumor invasion and metastasis. The adaptation of cells to hypoxia appears to be mediated through hypoxia-inducible factor-1α (HIF-1α). HIF-1α is said to be associated with malignant transformation of epithelium in other sites.
The aim of this study was to investigate the relationship between the expression of HIF-1α in OSMF and its role in malignant transformation.
A retrospective study which included 20 histopathologically diagnosed cases of OSF was conducted. A qualitative evaluation of HIF-1α was performed. Statistical analysis was carried out using the IBM Statistical Package for Social Sciences 20.0 version (IBM Corporation, Armonk, NY, USA).
Results showed an increased expression of HIF-1α in OSF.
HIF-1α appears to play a role in malignant transformation of OSF.
口腔黏膜下纤维化（OSF）是一种主要见于亚洲裔人群的癌前病变。约7%-12%的OSF患者会发展为口腔鳞状细胞癌。OSF的形态学特征，尤其是纤维化，提示病变组织中可能存在缺氧环境。新生血管形成和糖酵解增加，是对缺氧微环境的适应性变化，与肿瘤侵袭和转移相关。细胞对缺氧的适应似乎是通过缺氧诱导因子-1α（HIF-1α）介导的。据说HIF-1α与其他部位上皮的恶性转化有关。
本研究旨在探讨HIF-1α在口腔黏膜下纤维化中的表达与其在恶性转化中的作用之间的关系。
进行一项回顾性研究，纳入20例经组织病理学诊断的OSF病例。对HIF-1α进行定性评估。使用IBM社会科学统计软件包20.0版（美国纽约州阿蒙克市IBM公司）进行统计分析。
结果显示OSF中HIF-1α表达增加。
HIF-1α似乎在OSF的恶性转化中起作用。
