口腔鳞状细胞癌中的上皮-间质转化：对分子机制及临床意义的深入洞察
Epithelial-mesenchymal transition in oral squamous cell carcinoma: An insight into molecular mechanisms and clinical implications.
作者信息
Jayanthi P, Varun B R, Selvaraj J
机构信息
Department of Oral and Maxillofacial Pathology, Azeezia College of Dental Sciences and Research, Kollam, Kerala, India.
Department of Oral and Maxillofacial Pathology, PMS College of Dental Sciences and Research, Thiruvananthapuram, Kerala, India.
出版信息
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):189. doi: 10.4103/jomfp.JOMFP_334_19. Epub 2020 May 8.
Abstract
Epithelial-mesenchymal transition (EMT) is an important event in embryonic development, fibrosis and cancer invasion. During cancer progression, the activation of EMT permits cancer cells to acquire migratory, invasive and stem-like properties. Despite recent advances in treatment, there is no improvement in the 5-year overall survival rate of oral squamous cell carcinoma (OSCC). Local recurrence and lymph node metastasis are considered to be mainly responsible for the low survival rate in OSCC. EMT plays a major role in local recurrence and lymph node metastasis of oral cancer. This review article addresses the clinical implications of EMT in OSCC and explains the molecular mechanisms of EMT, highlighting the cadherin switching and signaling pathways involved.
摘要
上皮-间质转化（EMT）是胚胎发育、纤维化和癌症侵袭过程中的一个重要事件。在癌症进展过程中，EMT的激活使癌细胞获得迁移、侵袭和干细胞样特性。尽管近年来治疗取得了进展，但口腔鳞状细胞癌（OSCC）的5年总生存率并无改善。局部复发和淋巴结转移被认为是OSCC生存率低的主要原因。EMT在口腔癌的局部复发和淋巴结转移中起主要作用。这篇综述文章阐述了EMT在OSCC中的临床意义，并解释了EMT的分子机制，重点介绍了涉及的钙黏蛋白转换和信号通路。
相似文献
1
Epithelial-mesenchymal transition in oral squamous cell carcinoma: An insight into molecular mechanisms and clinical implications.口腔鳞状细胞癌中的上皮-间质转化：对分子机制及临床意义的深入洞察
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):189. doi: 10.4103/jomfp.JOMFP_334_19. Epub 2020 May 8.
2
Epithelial-mesenchymal transition in oral squamous cell carcinoma.口腔鳞状细胞癌中的上皮-间质转化
ISRN Oncol. 2012;2012:681469. doi: 10.5402/2012/681469. Epub 2012 Mar 29.
3
Cadherin switching in oral squamous cell carcinoma: A clinicopathological study.口腔鳞状细胞癌中的钙黏蛋白转换：一项临床病理研究。
J Oral Biol Craniofac Res. 2023 Jul-Aug;13(4):486-494. doi: 10.1016/j.jobcr.2023.05.001. Epub 2023 May 31.
4
EMT Dynamics in Lymph Node Metastasis of Oral Squamous Cell Carcinoma.口腔鳞状细胞癌淋巴结转移中的上皮-间质转化动态变化
Cancers (Basel). 2024 Mar 18;16(6):1185. doi: 10.3390/cancers16061185.
5
Bovine lactoferrin reverses programming of epithelial-to-mesenchymal transition to mesenchymal-to-epithelial transition in oral squamous cell carcinoma.牛乳铁蛋白可逆转口腔鳞状细胞癌中上皮-间充质转化的编程为间充质-上皮转化。
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):142-147. doi: 10.1016/j.bbrc.2018.10.193. Epub 2018 Nov 8.
6
Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma.促进口腔黏膜下纤维化和口腔鳞状细胞癌上皮-间质转化的信号通路
Jpn Dent Sci Rev. 2020 Nov;56(1):97-108. doi: 10.1016/j.jdsr.2020.07.002. Epub 2020 Aug 22.
7
HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma.HOXC10通过WNT-EMT信号通路促进口腔鳞状细胞癌的迁移和侵袭。
J Cancer. 2019 Jul 25;10(19):4540-4551. doi: 10.7150/jca.30645. eCollection 2019.
8
Loss of VHL expression contributes to epithelial-mesenchymal transition in oral squamous cell carcinoma.VHL表达缺失促进口腔鳞状细胞癌的上皮-间质转化。
Oral Oncol. 2014 Sep;50(9):809-17. doi: 10.1016/j.oraloncology.2014.06.007. Epub 2014 Jul 2.
9
Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasis.miR-204的抑制使口腔鳞状细胞癌能够促进癌症干性、上皮-间质转化特征和淋巴结转移。
Oncotarget. 2016 Apr 12;7(15):20180-92. doi: 10.18632/oncotarget.7745.
10
Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis.SIRT1在口腔鳞状细胞癌转移中上皮-间质转化调控中的作用
Mol Cancer. 2014 Nov 26;13:254. doi: 10.1186/1476-4598-13-254.
引用本文的文献
1
Integrated analysis of non‑coding RNAs (HOTAIR and miR‑130a) and their cross‑talk with TGF‑β1, SIRT1 and E‑cadherin as potential biomarkers in colorectal cancer.非编码RNA（HOTAIR和miR-130a）的综合分析及其与TGF-β1、SIRT1和E-钙黏蛋白的相互作用作为结直肠癌潜在生物标志物的研究
Oncol Lett. 2025 Jan 3;29(3):116. doi: 10.3892/ol.2025.14863. eCollection 2025 Mar.
2
FNDC5 affects invasion and migration of oral cancer by inhibiting PI3K/Akt/Snail signaling pathway.FNDC5 通过抑制 PI3K/Akt/Snail 信号通路影响口腔癌细胞的侵袭和迁移。
Sci Rep. 2024 Nov 6;14(1):26881. doi: 10.1038/s41598-024-78391-6.
3
A Comparative immunohistochemical analysis of epithelial-mesenchymal transition biomarkers in odontogenic keratocyst, dentigerous cyst, and radicular cyst.牙源性角化囊肿、含牙囊肿和根端囊肿上皮-间质转化生物标志物的比较免疫组织化学分析
Dent Res J (Isfahan). 2024 Aug 21;21:46. eCollection 2024.
4
NK cell based immunotherapy against oral squamous cell carcinoma.基于自然杀伤细胞的免疫疗法治疗口腔鳞状细胞癌。
Front Immunol. 2024 Aug 13;15:1440764. doi: 10.3389/fimmu.2024.1440764. eCollection 2024.
5
Apigenin suppresses the low oxaliplatin-induced epithelial-mesenchymal transition in oral squamous cell carcinoma cells via LINC00857.芹菜素通过LINC00857抑制低剂量奥沙利铂诱导的口腔鳞状细胞癌细胞上皮-间质转化。
Transl Cancer Res. 2024 May 31;13(5):2164-2174. doi: 10.21037/tcr-23-2335. Epub 2024 May 29.
6
Vitamin D-metabolizing enzyme CYP24A1 affects oncogenic behaviors of oral squamous cell carcinoma and its prognostic implication.维生素 D 代谢酶 CYP24A1 影响口腔鳞状细胞癌的致癌行为及其预后意义。
Med Mol Morphol. 2024 Sep;57(3):185-199. doi: 10.1007/s00795-024-00387-y. Epub 2024 May 21.
7
CSCE-cadherin immunohistochemistry panel predicts poor prognosis in oral squamous cell carcinoma.钙黏蛋白免疫组织化学检测面板预测口腔鳞状细胞癌预后不良。
Sci Rep. 2024 May 8;14(1):10583. doi: 10.1038/s41598-024-55594-5.
8
AKR1B10 accelerates glycolysis through binding HK2 to promote the malignant progression of oral squamous cell carcinoma.醛酮还原酶1B10通过与己糖激酶2结合加速糖酵解，促进口腔鳞状细胞癌的恶性进展。
Discov Oncol. 2024 Apr 26;15(1):132. doi: 10.1007/s12672-024-00996-0.
9
Role of prognostic gene DKK1 in oral squamous cell carcinoma.预后基因DKK1在口腔鳞状细胞癌中的作用。
Oncol Lett. 2023 Dec 12;27(2):52. doi: 10.3892/ol.2023.14184. eCollection 2024 Feb.
10
Role of desmosomal components in the initiation and metastasis of oral cancer-A review.桥粒成分在口腔癌发生和转移中的作用——综述
J Oral Maxillofac Pathol. 2023 Jul-Sep;27(3):528-532. doi: 10.4103/jomfp.jomfp_8_23. Epub 2023 Sep 12.
本文引用的文献
1
Dancing from bottoms up - Roles of the POZ-ZF transcription factor Kaiso in Cancer.从底部跳舞 - POZ-ZF 转录因子 Kaiso 在癌症中的作用。
Biochim Biophys Acta Rev Cancer. 2019 Jan;1871(1):64-74. doi: 10.1016/j.bbcan.2018.10.005. Epub 2018 Nov 9.
2
Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity.上皮-间充质转化：表观遗传重编程驱动细胞可塑性。
Trends Genet. 2017 Dec;33(12):943-959. doi: 10.1016/j.tig.2017.08.004. Epub 2017 Sep 14.
3
Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion.MT1-MMP 依赖性癌细胞侵袭的细胞和分子机制。
Annu Rev Cell Dev Biol. 2016 Oct 6;32:555-576. doi: 10.1146/annurev-cellbio-111315-125227. Epub 2016 Aug 8.
4
EMT: 2016.EMT：2016 年。
Cell. 2016 Jun 30;166(1):21-45. doi: 10.1016/j.cell.2016.06.028.
5
MicroRNA Regulation of Epithelial to Mesenchymal Transition.微小RNA对上皮-间质转化的调控
J Clin Med. 2016 Jan 14;5(1):8. doi: 10.3390/jcm5010008.
6
Epithelial-mesenchymal transition is regulated at post-transcriptional levels by transforming growth factor-β signaling during tumor progression.上皮-间质转化在肿瘤进展过程中受转化生长因子-β信号通路在转录后水平调控。
Cancer Sci. 2015 May;106(5):481-8. doi: 10.1111/cas.12630. Epub 2015 Mar 9.
7
Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition.Snail1和Snail2锌指在E-钙黏蛋白抑制及上皮-间质转化中的不同作用
J Biol Chem. 2014 Jan 10;289(2):930-41. doi: 10.1074/jbc.M113.528026. Epub 2013 Dec 1.
8
EMT and MET in metastasis: where are the cancer stem cells?上皮间质转化（EMT）和间质上皮转化（MET）在转移中的作用：癌症干细胞在哪里？
Cancer Cell. 2012 Dec 11;22(6):699-701. doi: 10.1016/j.ccr.2012.11.009.
9
Epithelial-mesenchymal transition in oral squamous cell carcinoma.口腔鳞状细胞癌中的上皮-间质转化
ISRN Oncol. 2012;2012:681469. doi: 10.5402/2012/681469. Epub 2012 Mar 29.
10
Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition.Snail1 和 twist 在 EMT 过程中共同调控 ZEB1 表达的功能。
J Biol Chem. 2011 Apr 8;286(14):12024-32. doi: 10.1074/jbc.M110.168625. Epub 2011 Feb 12.
Zotero 插件