Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Department of Ophthalmology/Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Front Immunol. 2020 May 21;11:975. doi: 10.3389/fimmu.2020.00975. eCollection 2020.
Experimental autoimmune uveoretinitis (EAU) is a mouse model of human autoimmune uveitis. EAU spontaneously resolves and is marked by ocular autoantigen-specific regulatory immunity in the spleen. Kallikrein binding protein (KBP) or kallistatin is a serine proteinase inhibitor that inhibits angiogenesis and inflammation, but its role in autoimmune uveitis has not been explored. We report that T cells activation is inhibited and EAU is attenuated in human KBP (HKBP) mice with no significant difference in the Treg population that we previously identified both before and after recovery from EAU. Moreover, following EAU immunization HKBP mice have potent ocular autoantigen specific regulatory immunity that is functionally suppressive.
实验性自身免疫性葡萄膜炎（EAU）是一种人类自身免疫性葡萄膜炎的小鼠模型。EAU 可自发缓解，其特征是脾脏中存在眼内自身抗原特异性调节免疫。激肽释放酶结合蛋白（KBP）或卡利斯塔坦是一种丝氨酸蛋白酶抑制剂，可抑制血管生成和炎症，但它在自身免疫性葡萄膜炎中的作用尚未得到探索。我们报告称，在我们之前在 EAU 缓解前后都鉴定出的 Treg 群体中，人 KBP（HKBP）小鼠的 T 细胞激活受到抑制，EAU 减轻，且没有明显差异。此外，在 EAU 免疫接种后，HKBP 小鼠具有强大的眼内自身抗原特异性调节免疫，具有功能抑制作用。
