Wen Fengyun, Xia Qiao, Zhang Hui, Shia Haipeng, Rajesh Amin, Wu Yanling, Yang Yi, Yang Zaiqing
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan, China.
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China.
Int J Endocrinol. 2020 May 18;2020:9767926. doi: 10.1155/2020/9767926. eCollection 2020.
Resistin is associated with metabolic syndrome and inflammatory conditions. Many studies have suggested that resistin inhibits the accumulation of glycogen; however, the exact mechanisms of resistin-induced decrease in glycogen content remain unclear. Keratin 8 is a typical epithelial intermediate filament protein, but numerous studies suggest a vital role of K8 in glucose metabolism. However, it is still not known whether K8 participates in the mediation of resistin-induced reduction of cellular glycogen accumulation. In this study, we found that resistin upregulated expression of the p65 subunit of NF-B, which led to the promotion of K8 transcriptional expression; in turn, the expression of K8 inhibited glycogen accumulation in HepG2 cells.
抵抗素与代谢综合征及炎症状态相关。许多研究表明，抵抗素会抑制糖原积累；然而，抵抗素导致糖原含量降低的确切机制仍不清楚。角蛋白8是一种典型的上皮中间丝蛋白，但众多研究表明K8在葡萄糖代谢中起重要作用。然而，K8是否参与介导抵抗素诱导的细胞糖原积累减少尚不清楚。在本研究中，我们发现抵抗素上调了NF-κB p65亚基的表达，这导致K8转录表达的促进；反过来，K8的表达抑制了HepG2细胞中的糖原积累。
