Auteri A, Saletti M, Blardi P, Di Perri T
Istituto di Patologia Medica e Metodologia Clinica, Università degli Studi di Siena, Policlinico Le Scotte, Italy.
Int J Tissue React. 1988;10(4):217-21.
The complement system has a pivotal role in the antiinflammatory reaction. Furthermore it has been shown that the sequential activation of the complement system may be inhibited at various levels by pharmacological agents such as non-steroidal antiinflammatory drugs. Therefore the eventual anticomplementary action of Nimesulide was assessed in vitro in various experimental models. It was found that it blocks immunohaemolysis in vitro and has a direct effect on serum complement activity. Nimesulide blocks the activation of third complement and this explains why the drug is also inhibitory on the inulin-induced haemolytic reaction.
补体系统在抗炎反应中起关键作用。此外，已表明补体系统的顺序激活可在不同水平上被非甾体抗炎药等药物抑制。因此，在各种实验模型中对尼美舒利的最终抗补体作用进行了体外评估。发现它在体外阻断免疫溶血，并且对血清补体活性有直接作用。尼美舒利阻断第三补体的激活，这就解释了为什么该药物对菊粉诱导的溶血反应也有抑制作用。
