结直肠癌癌前阶段的免疫斗争：聚焦免疫细胞组成、功能及细胞因子产物
Immune battle at the premalignant stage of colorectal cancer: focus on immune cell compositions, functions and cytokine products.
作者信息
Cui Guanglin
机构信息
Research Group of Gastrointestinal Diseases, The Second Affiliated Hospital of Zhengzhou University Zhengzhou, China.
Faculty of Health Science, Nord University, Campus Levanger Norway.
出版信息
Am J Cancer Res. 2020 May 1;10(5):1308-1320. eCollection 2020.
Abstract
It is now widely accepted that most human cancers, including colorectal cancers (CRCs), develop from premalignant lesions through a long-term multistep process. Host immunity is a key determinant that maintains most premalignant lesions in a stable state via immunosurveillance. However, premalignant cells use diverse strategies to escape host immunosurveillance. A switch in the immune function from immunosurveillance to immunosuppression facilitates the progression of premalignant lesions to established CRCs. This review summarizes the recent progress in understanding alterations in the immune landscape, including immune cell compositions, functions and cytokine products, in the premalignant stage of CRC and provides an updated discussion on its translational significance along the colorectal adenoma-carcinoma sequence.
摘要
现在人们普遍认为，包括结直肠癌（CRC）在内的大多数人类癌症都是通过长期的多步骤过程从癌前病变发展而来的。宿主免疫是通过免疫监视将大多数癌前病变维持在稳定状态的关键决定因素。然而，癌前细胞会采用多种策略来逃避宿主免疫监视。免疫功能从免疫监视转变为免疫抑制有助于癌前病变发展为已确诊的结直肠癌。这篇综述总结了在理解结直肠癌癌前阶段免疫格局变化方面的最新进展，包括免疫细胞组成、功能和细胞因子产物，并就其在结直肠腺瘤-癌序列中的转化意义提供了最新讨论。
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