Jakobiec Frederick A, Cortes Barrantes Paula, Ma Lina, Lee Nahyoung Grace
David G. Cogan Laboratory of Ophthalmic Pathology, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston, Massachusetts, USA.
Department of Oculoplastics, Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston, Massachusetts, USA.
Ocul Oncol Pathol. 2020 May;6(3):151-158. doi: 10.1159/000501369. Epub 2019 Oct 8.
A 55-year-old woman developed a painless, non-ulcerated left upper eyelid swelling over 6 months. Examination disclosed a fluctuant mass that permitted movement of the eyelid skin over the lesion. A full-thickness eyelid resection contained a well-encapsulated cyst with milky contents that was predominantly located in the tarsus. The cyst's lining was partially composed of segments of ciliated respiratory-type and non-keratinizing squamous epithelia. Immunohistochemical evaluation with cytokeratins 17, 18, and 19 confirmed the staining pattern of a respiratory-type epithelial cell (whether or not cilia were present in the non-squamous epithelial zones). In the squamous region, entirely different cytokeratin results were obtained vis-a-vis the non-squamous regions of the lining. The current lesion is interpreted as congenital and representing an in situ persistence of embryonic ciliated glandular epithelium that normally exists only transitorily. A more remote possibility is that the lesion was the result of ectopic epithelial cells displaced from an adjacent sinus. A recurrence has not developed during 6 months of follow-up.
一名55岁女性在6个月内出现左上眼睑无痛性、非溃疡性肿胀。检查发现一个波动性肿块，眼睑皮肤可在病变上移动。全层眼睑切除术切除的囊肿包膜完整，内容物呈乳白色，主要位于睑板。囊肿内衬部分由纤毛呼吸型和非角化鳞状上皮组成。细胞角蛋白17、18和19的免疫组化评估证实了呼吸型上皮细胞的染色模式（无论非鳞状上皮区域是否存在纤毛）。在鳞状区域，内衬的鳞状区域与非鳞状区域获得了完全不同的细胞角蛋白结果。目前的病变被解释为先天性病变，代表胚胎期纤毛腺上皮的原位持续存在，而这种上皮通常仅短暂存在。另一种可能性较小的情况是，该病变是由相邻鼻窦移位的异位上皮细胞所致。随访6个月期间未出现复发。
