Torres German, Mourad Mervat, Leheste Joerg R
Department of Counseling and Clinical Psychology, Medaille College, Buffalo, New York USA.
Department of Clinical Specialties, New York College of Osteopathic Medicine, Old Westbury, New York USA.
Heliyon. 2020 May 29;6(5):e04047. doi: 10.1016/j.heliyon.2020.e04047. eCollection 2020 May.
Oxytocin plays an important role in the regulation of parturition as this peptide hormone promotes uterine smooth muscle contractility in gravid women undergoing labor. Here, we review the impact of Pitocin administration on behavioral outcomes in the pediatric population. Pitocin is a synthetic preparation of oxytocin widely used in the obstetric practice for the management of labor and postpartum hemorrhage. We begin by tracing the neuroanatomy of oxytocin-containing cells from an evolutionary perspective and then summarize key findings on behavioral and neural activity reported from offspring dosed with Pitocin during vaginal delivery. Finally, we discuss future directions that are experimentally tractable for understanding the developmental consequences of Pitocin administration on a small but growing subset of children worldwide. Given that fetal past experiences can shape the future behavior of the adult, further work on oxytocin signaling pathways will provide valuable references and insights for early-brain development and state-dependent regulation of behavioral outcome.
催产素在分娩调节中发挥着重要作用，因为这种肽类激素可促进处于分娩期的孕妇子宫平滑肌收缩。在此，我们综述了使用缩宫素对儿科人群行为结果的影响。缩宫素是一种催产素的合成制剂，在产科实践中广泛用于引产和产后出血的处理。我们首先从进化角度追溯含催产素细胞的神经解剖结构，然后总结经阴道分娩时给予缩宫素的后代在行为和神经活动方面的关键研究结果。最后，我们讨论了未来的研究方向，这些方向在实验上易于操作，有助于理解使用缩宫素对全球一小部分但数量不断增加的儿童发育产生的影响。鉴于胎儿过去的经历会塑造成年后的未来行为，进一步研究催产素信号通路将为早期脑发育和行为结果的状态依赖性调节提供有价值的参考和见解。
