Gottlieb Mark M
Independent Research, 1700 Shattuck Avenue, #114, Berkeley, CA 94709-3402, USA.
Behav Brain Res. 2016 Feb 1;298(Pt B):246-7. doi: 10.1016/j.bbr.2015.10.053. Epub 2015 Nov 3.
The risk of Pitocin as a cause of autism attributable to oxytocin receptor desensitization in the brain of the fetus is evaluated in terms of a mathematical model. A composite unit, D, for oxytocin receptor desensitization levels is established with the form ((IU-h)/ml)E-3, where IU is the international unit for oxytocin. The desensitization values for oxytocin receptor desensitization at a concentration of 10 nmol of oxytocin per liter for 3, 4.2 and 6h corresponding to 0%, 50% and 100% desensitization are calculated to be 15 D, 21 D, and 30 D, respectively. The permeability of the blood-brain barrier in the fetus to oxytocin is discussed, and the upper limit of the concentration of Pitocin in the placenta, and its possible diffusion into the blood and brain of the fetus, is calculated for a routine dose of 6 milli U per minute of Pitocin over a 12h labor. This dose of Pitocin is shown to result in a desensitization value in units of D that is more than a factor of 10 below the 0% desensitization value of 15 D. This indicates that routine doses of Pitocin are not a significant cause of autism attributable to oxytocin receptor desensitization. This is consistent with the findings of a major epidemiological study of the association of Pitocin with autism in Denmark entitled, "Oxytocin-augmented labor and risk for males", Behavioral Brain Research, May 1, 2015; 284:207-212, which found no association between the use of Pitocin during labor and the incidence of autism for females, and a modest association for males.
通过一个数学模型评估了因胎儿大脑中催产素受体脱敏而导致自闭症的缩宫素风险。建立了一个用于催产素受体脱敏水平的复合单位D，其形式为((IU - h)/ml)E - 3，其中IU是催产素的国际单位。计算得出，在每升含10 nmol催产素的浓度下，分别作用3小时、4.2小时和6小时时，对应0%、50%和100%脱敏的催产素受体脱敏值分别为15 D、21 D和30 D。讨论了胎儿血脑屏障对催产素的通透性，并针对分娩12小时期间每分钟6毫单位的常规缩宫素剂量，计算了胎盘内缩宫素浓度的上限及其可能扩散到胎儿血液和大脑中的情况。结果表明，该剂量的缩宫素导致的以D为单位的脱敏值比15 D的0%脱敏值低10倍以上。这表明常规剂量的缩宫素并非因催产素受体脱敏而导致自闭症的重要原因。这与丹麦一项关于缩宫素与自闭症关联的大型流行病学研究结果一致，该研究题为《催产素增强分娩与男性风险》，发表于《行为脑科学》2015年5月1日；284:207 - 212，研究发现分娩期间使用缩宫素与女性自闭症发病率之间无关联，与男性有适度关联。
