Carbon Dioxide Activation Center (CADIAC), Department of Chemistry and the, Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, 8000, Aarhus C, Denmark.
Department of Engineering, Aarhus University, Åbogade 40, 8200, Aarhus N, Denmark.
Chempluschem. 2020 Jul;85(7):1529-1533. doi: 10.1002/cplu.202000319. Epub 2020 Jun 8.
This Personal Account describes the development of air-stable and solid precursors for on-demand release of carbon monoxide. In combination with the development of a two-chamber reactor, COware®, CO liberation can be achieved under safe working conditions, as well as allowing transition metal-mediated carbonylations with stoichiometric carbon monoxide. Particularly appealing is the adaptability of this chemical technology for the preparation of carbon isotope labeled bioactive compounds.
本个人帐户描述了用于按需释放一氧化碳的空气稳定和固体前体的开发。与双室反应器 COware®的开发相结合，可以在安全的工作条件下实现 CO 的释放，并允许使用化学计量一氧化碳的过渡金属介导的羰基化反应。特别吸引人的是这种化学技术在制备碳同位素标记生物活性化合物方面的适应性。
