Instituto Nacional de Salud Pública. Cuernavaca, Morelos, Mexico.
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Mexico City, Mexico.
Salud Publica Mex. 2020 May-Jun;62(3):246-254. doi: 10.21149/10903.
To determine the association between polypharmacy and multiple health-related outcomes in older adults.
We carried out a cross-sectional analysis with 274 community-dwelling older adults aged ≥60 years in Mexico City. We used the following health-related outcomes: frailty, dementia, functional capacity, falls, disability, and quality of life. The main exposure was polypharmacy (chronic use of six or more drugs). Ordinal logistic regression, binary logistic regression, Poisson regression, and linear regression models were used to estimate the association between polypharmacy and the outcomes analyzed.
Polypharmacy was present in 45% of the sample. Polypharmacy was significantly associated with frailty status, and marginally, with dementia. We also observed significant associations for instrumental activities of daily living, falls, disability, and quality of life.
Given that polypharmacy has reached levels of a global epidemic, it is necessary to take radical actions to reduce the concomitant problems of the use of multiple drugs.
确定老年人中药物滥用与多种健康相关结局之间的关联。
我们对墨西哥城 274 名年龄≥60 岁的社区居住老年人进行了横断面分析。我们使用以下健康相关结局：虚弱、痴呆、功能能力、跌倒、残疾和生活质量。主要暴露因素为药物滥用（长期使用六种或六种以上药物）。使用有序逻辑回归、二元逻辑回归、泊松回归和线性回归模型来估计药物滥用与分析结局之间的关联。
在样本中，有 45%的人存在药物滥用。药物滥用与虚弱状态显著相关，与痴呆状态呈边缘相关。我们还观察到与工具性日常生活活动、跌倒、残疾和生活质量有显著关联。
鉴于药物滥用已经达到全球流行的程度，有必要采取激进措施来减少同时使用多种药物所带来的问题。
