J Refract Surg. 2020 Jun 1;36(6):406-413. doi: 10.3928/1081597X-20200429-01.
To evaluate a new non-ablative and adjustable procedure for laser ablative refractive corneal surgery in hyperopia using the injection of a biocompatible liquid filler material into a stromal pocket.
A total of 120 stromal pockets were created using a clinical femtosecond laser system in 96 rabbit corneoscleral discs and 24 whole globes. Pockets were cut at a depth of 120 or 250 µm below the epithelial surface. Hyaluronic acid was injected manually into the pocket. To determine the refractive changes, three-dimensional optical coherence tomography images and a specifically developed picture recognition Matlab (The Mathworks) routine were used.
After injection, a steepening of the anterior and flattening of the posterior corneal surface was observed, which led to hyperopic correction. The two main factors determining the amount of correction were the pocket depth and the injected volume. After the pocket was homogeneously filled, an initial refractive increase was observed, followed by a linear relation between the injected volume and the refraction increase.
This possible clinical protocol for controlled refraction correction of hyperopia suggests a potential readjustable clinical application. [J Refract Surg. 2020;36(6):406-414.].
评估一种新的非消融性和可调节的远视激光消融性角膜手术方法，即在基质囊中注射一种生物相容性的液体填充材料。
使用临床飞秒激光系统在 96 个兔角膜巩膜瓣和 24 个全眼球中创建了总共 120 个基质囊。在距上皮表面 120 或 250 µm 的深度切开口袋。手动将透明质酸注入囊中。为了确定屈光变化，使用了三维光学相干断层扫描图像和专门开发的图片识别 Matlab（Mathworks）程序。
注入后，观察到前表面变陡，后表面变平，导致远视矫正。决定矫正量的两个主要因素是口袋深度和注入量。当口袋均匀填充后，会观察到初始屈光增加，然后是注入量与屈光增加之间的线性关系。
这种可能的用于远视的可控制折射矫正的临床方案表明了一种潜在的可调节的临床应用。[J Refract Surg. 2020;36(6):406-414.].
