Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, China; Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China; Department of Mental Health, Shanxi Medical University, Taiyuan, China.
Psychiatry Res. 2020 Aug;290:113141. doi: 10.1016/j.psychres.2020.113141. Epub 2020 May 29.
To evaluate the efficacy of repetitive transcranial magnetic stimulation (rTMS) on auditory hallucinations (AH) in schizophrenia, we conducted a meta-analysis of currently available randomized control studies (RCTs). Electronic databases were searched to identify relevant literatures. Only RCTs that met the inclusion criteria were enrolled for further analysis. Standard mean difference (SMD) and 95% confidence interval (CI) values were used to evaluate the effects of rTMS. The overall robustness of the results was assessed by analyzing the influence of single studies. Publication bias was analyzed using funnel plots. Eleven eligible studies were included in this meta-analysis. Auditory hallucinations improved more in the rTMS group than in the sham group (SMD = -0.27, 95%CI = -0.51 to -0.03). However, this result was not stable after sensitivity analysis. Despite a moderate effect for rTMS on AH, future definitive trials of rTMS with rigorous processes and high-quality reporting are needed.
为了评估重复经颅磁刺激(rTMS)对精神分裂症幻听(AH)的疗效，我们对目前可用的随机对照研究(RCT)进行了荟萃分析。电子数据库被检索以识别相关文献。只有符合纳入标准的 RCT 才被纳入进一步分析。标准均数差(SMD)和 95%置信区间(CI)值用于评估 rTMS 的效果。通过分析单个研究的影响来评估结果的整体稳健性。使用漏斗图分析发表偏倚。这项荟萃分析纳入了 11 项符合条件的研究。rTMS 组的幻听改善程度高于假刺激组(SMD=-0.27，95%CI=-0.51 至-0.03)。然而，在敏感性分析后，这一结果并不稳定。尽管 rTMS 对 AH 有中度效果，但仍需要进行具有严格程序和高质量报告的 rTMS 后续确证性试验。
