Segal M
Center for Neurosciences, Weizmann Institute of Science, Rehovot, Israel.
Neuroscience. 1988 Dec;27(3):905-9. doi: 10.1016/0306-4522(88)90193-5.
Activity of CA1 neurons was recorded in rat hippocampal slices with a lidocaine-derived QX-572-filled micropipette. The QX compound abolished Na action potentials as reported earlier. In addition it reduced markedly the burst slow afterhyperpolarization seen in these neurons in response to a depolarizing current pulse. It also modified responses to neurotransmitter substances associated with changes in K currents, acetylcholine and serotonin. QX-filled micropipettes can therefore provide some insight into mechanisms of action of certain neurotransmitters in the brain but they cannot be used as selective blockers of Na currents.
用充满利多卡因衍生物QX - 572的微电极在大鼠海马切片中记录CA1神经元的活动。如先前报道的那样，QX化合物消除了钠动作电位。此外，它还显著降低了这些神经元在去极化电流脉冲刺激下出现的爆发性慢后超极化。它还改变了与钾电流变化相关的神经递质物质、乙酰胆碱和5 - 羟色胺的反应。因此，充满QX的微电极可以为大脑中某些神经递质的作用机制提供一些见解，但它们不能用作钠电流的选择性阻断剂。
