Yu Jane, Kimble Benjamin, Norris Jacqueline M, Govendir Merran
Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Sydney, NSW 2006, Australia.
Animals (Basel). 2020 Jun 8;10(6):1000. doi: 10.3390/ani10061000.
The pharmacokinetic profile of mefloquine was investigated as a preliminary study towards a potential treatment for feline coronavirus infections (such as feline infectious peritonitis) or feline calicivirus infections. Mefloquine was administered at 62.5 mg orally to seven clinically healthy cats twice weekly for four doses and mefloquine plasma concentrations over 336 h were measured using high pressure liquid chromatography (HPLC). The peak plasma concentration (Cmax) after a single oral dose of mefloquine was 2.71 ug/mL and time to reach Cmax (Tmax) was 15 h. The elimination half-life was 224 h. The plasma concentration reached a higher level at 4.06 ug/mL when mefloquine was administered with food. Adverse effects of dosing included vomiting following administration without food in some cats. Mild increases in serum symmetric dimethylarginine (SDMA), but not creatinine, concentrations were observed. Mefloquine may provide a safe effective treatment for feline coronavirus and feline calicivirus infections in cats.
作为对猫冠状病毒感染（如猫传染性腹膜炎）或猫杯状病毒感染潜在治疗方法的初步研究，对甲氟喹的药代动力学特征进行了调查。对7只临床健康的猫每周口服两次62.5毫克甲氟喹，共给药4次，采用高压液相色谱法（HPLC）测定336小时内的甲氟喹血浆浓度。单次口服甲氟喹后的血浆峰浓度（Cmax）为2.71微克/毫升，达到Cmax的时间（Tmax）为15小时。消除半衰期为224小时。与食物一起服用甲氟喹时，血浆浓度达到较高水平，为4.06微克/毫升。给药的不良反应包括一些猫在未进食时给药后出现呕吐。观察到血清对称二甲基精氨酸（SDMA）浓度轻度升高，但肌酐浓度未升高。甲氟喹可能为猫的猫冠状病毒和猫杯状病毒感染提供一种安全有效的治疗方法。
