Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint-Antoine, Service de Parasitologie-Mycologie, Paris, France.
Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, Paris, France.
Front Immunol. 2020 May 22;11:1041. doi: 10.3389/fimmu.2020.01041. eCollection 2020.
is an environmental filamentous fungus that can be pathogenic for humans, wherein it is responsible for a large variety of clinical forms ranging from allergic diseases to life-threatening disseminated infections. The contamination occurs by inhalation of conidia present in the air, and the first encounter of this fungus in the human host is most likely with the bronchial epithelial cells. Although alveolar macrophages have been widely studied in the -lung interaction, increasing evidence suggests that bronchial epithelium plays a key role in responding to the fungus. This review focuses on the innate immune response of the bronchial epithelial cells against , the predominant pathogenic species. We have also detailed the molecular interactants and the effects of the different modes of interaction between these cells and the fungus.
烟曲霉是一种环境丝状真菌，可对人类致病，它可引起多种临床病症，从过敏疾病到危及生命的全身性感染。其通过吸入空气中的分生孢子而发生污染，该真菌在人体宿主中的首次接触很可能是与支气管上皮细胞。尽管肺泡巨噬细胞在肺部与真菌的相互作用中已被广泛研究，但越来越多的证据表明，支气管上皮细胞在对真菌的反应中起着关键作用。本综述重点介绍了支气管上皮细胞针对主要致病种烟曲霉的固有免疫反应。我们还详细介绍了这些细胞与真菌之间不同相互作用模式的分子相互作用物和作用。
