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植入猪体内的生物和机械主动脉瓣假体下游的速度场和湍流应力。

Velocity fields and turbulent stresses downstream of biological and mechanical aortic valve prostheses implanted in pigs.

作者信息

Hasenkam J M, Pedersen E M, Ostergaard J H, Nygaard H, Paulsen P K, Johannsen G, Schurizek B A

机构信息

Department of Thoracic and Cardiovascular Surgery, Aarhus Kommunehospital, Denmark.

出版信息

Cardiovasc Res. 1988 Jul;22(7):472-83. doi: 10.1093/cvr/22.7.472.

Abstract

Since detailed knowledge about velocity fields downstream of heart valve prostheses obtained from in vitro studies has not been followed up by similar detailed studies in vivo a pig model for acute velocity field studies downstream of aortic valve prostheses was established. Two mechanical and two bioprosthetic valves were studied and a dynamic three dimensional visualisation of velocity fields one diameter downstream performed under different haemodynamic conditions in a total of 22 pigs. The Ionescu-Shiley pericardial valve had velocity fields very similar to the normal native porcine aortic valve. The Edwards-Carpentier porcine valve caused a jet type flow, and the valve design of the St Jude Medical and Björk-Shiley Monostrut valves was reflected in the velocity profile. Normalised (mean(SEM] systolic Reynolds normal stresses in the total cross sectional area were: native porcine 15(1.5) Nm-2; St Jude Medical 24(3.4) Nm-2; Björk-Shiley Monostrut 25(1.6) Nm-2; Edwards-Carpentier Supra-annular 51(6.6) Nm-2; Ionescu-Shiley Pericardial 19(2.0) Nm-2. Reynolds normal stresses were higher in areas of rapidly changing or constantly high velocity gradients.

摘要

由于体外研究获得的关于心脏瓣膜假体下游速度场的详细知识尚未在体内进行类似的详细研究跟进,因此建立了一个用于急性研究主动脉瓣膜假体下游速度场的猪模型。研究了两个机械瓣膜和两个生物瓣膜,并在总共22头猪的不同血流动力学条件下,对下游一个直径处的速度场进行了动态三维可视化。伊奥内斯库 - 希利心包瓣膜的速度场与正常天然猪主动脉瓣膜非常相似。爱德华兹 - 卡朋蒂埃猪瓣膜导致喷射型血流,圣犹达医疗瓣膜和比约克 - 希利单支柱瓣膜的瓣膜设计反映在速度分布中。总横截面积归一化(均值(标准误))的收缩期雷诺法向应力为:天然猪瓣膜15(1.5) Nm-2;圣犹达医疗瓣膜24(3.4) Nm-2;比约克 - 希利单支柱瓣膜25(1.6) Nm-2;爱德华兹 - 卡朋蒂埃超环瓣51(6.6) Nm-2;伊奥内斯库 - 希利心包瓣膜19(2.0) Nm-2。在快速变化或持续高速度梯度的区域,雷诺法向应力更高。

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