Scanlon M J, Whorwood C B, Franks S, Reed M J, James V H
Department of Chemical Pathology St. Mary's Hospital Medical School, London, UK.
Clin Endocrinol (Oxf). 1988 Nov;29(5):529-38. doi: 10.1111/j.1365-2265.1988.tb03702.x.
There is currently much interest in measurements of 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (AdiolG) as a marker of peripheral androgen metabolism. We have therefore developed an assay to measure serum AdiolG levels and report that mean concentrations in hirsute (2.9 +/- 1.9 nmol/l, mean +/- SD, n = 15) and non-hirsute (1.9 +/- 0.6 nmol/l, n = 7) women with polycystic ovaries do not differ significantly from concentrations in normal women (2.2 +/- 0.8 nmol/l, n = 20). However, a correlation was found between serum AdiolG levels and Body Mass Index (r = 0.48, P less than 0.05) for women with polycystic ovaries, suggesting that weight may be an important factor in determining concentrations of this steroid conjugate. Serum AdiolG levels were significantly reduced in hypothyroid women (0.6 +/- 0.4 nmol/l, n = 5) and women receiving oral contraceptive therapy (0.6 +/- 0.4 nmol/l, n = 28) but increased in hyperthyroid women (4.0 +/- 0.6 nmol/l, n = 5). The results from this study do not support the hypothesis that serum AdiolG levels provide a marker of peripheral androgen metabolism in hirsute women and show that it is essential to exclude from such investigations any women with thyroid abnormalities or receiving oral contraceptive therapy.
目前，人们对测量5α-雄烷-3α,17β-二醇葡糖苷酸（AdiolG）作为外周雄激素代谢标志物非常感兴趣。因此，我们开发了一种测定血清AdiolG水平的方法，并报告多囊卵巢的多毛女性（2.9±1.9 nmol/l，平均值±标准差，n = 15）和非多毛女性（1.9±0.6 nmol/l，n = 7）的平均浓度与正常女性（2.2±0.8 nmol/l，n = 20）的浓度相比，差异无统计学意义。然而，发现多囊卵巢女性的血清AdiolG水平与体重指数之间存在相关性（r = 0.48，P<0.05），这表明体重可能是决定这种甾体共轭物浓度的一个重要因素。甲状腺功能减退女性（0.6±0.4 nmol/l，n = 5）和接受口服避孕药治疗的女性（0.6±0.4 nmol/l，n = 28）的血清AdiolG水平显著降低，但甲状腺功能亢进女性（4.0±0.6 nmol/l，n = 5）的血清AdiolG水平升高。本研究结果不支持血清AdiolG水平可作为多毛女性外周雄激素代谢标志物的假设，并表明在这类研究中必须排除任何甲状腺异常或接受口服避孕药治疗的女性。
