Greep N, Hoopes M, Horton R
J Clin Endocrinol Metab. 1986 Jan;62(1):22-7. doi: 10.1210/jcem-62-1-22.
We studied the kinetics and metabolism of tritiated 5 alpha-androstane-3 alpha-17 beta-diol glucuronide (3 alpha diolG) in normal and hirsute women. We found no difference in the MCR of 3 alpha diolG between normal and hirsute women [130 +/- 39 (+/- SD) vs. 157 +/- 81; P = NS]. The blood production rate was markedly increased in hirsute women (187 +/- 50 vs. 604 +/- 355 micrograms/day; P less than 0.001) and correlated well with the plasma 3 alpha diolG level (r = 0.96). In women, the conversion ratio of 3 alpha diolG to unconjugated 3 alpha diol or dihydrotestosterone was less than 1%, while the conversion ratio to dihydrotestosterone glucuronide was about 6%. We conclude that the elevated plasma levels of 3 alpha diolG characteristic of hirsutism reflect increased production of this androgen metabolite.
我们研究了氚标记的5α-雄烷-3α-17β-二醇葡糖苷酸（3α二醇G）在正常女性和多毛症女性中的动力学及代谢情况。我们发现，正常女性和多毛症女性之间3α二醇G的代谢清除率无差异[130±39（±标准差）对157±81；P=无显著性差异]。多毛症女性的血生成率显著升高（187±50对604±355微克/天；P<0.001），且与血浆3α二醇G水平密切相关（r=0.96）。在女性中，3α二醇G转化为未结合的3α二醇或双氢睾酮的转化率低于1%，而转化为双氢睾酮葡糖苷酸的转化率约为6%。我们得出结论，多毛症患者特征性的血浆3α二醇G水平升高反映了这种雄激素代谢产物生成增加。
