De Klomp Dierenartsen, De Klomp, the Netherlands.
Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
J Equine Vet Sci. 2020 Jul;90:102999. doi: 10.1016/j.jevs.2020.102999. Epub 2020 Apr 2.
It has been suggested that gluten may play a role in equine inflammatory small bowel disease (ISBD). Previous work showed an association between equine gluten-sensitive enteropathy and IgA antibodies to tissue transglutaminase (TGA) in serum. The purpose of this study is to investigate the prevalence of IgA antibodies to TGA in a group of healthy non-gluten-free sport ponies and to present a case of tentative gluten-sensitive enteropathy and dermatitis in a horse. Blood samples were obtained from 40 healthy jumping ponies. The ponies comprised 12 mares, 8 stallions, and 20 geldings with an average age of 9.0 ± 3.8 years (±SD; range 3-19 years). Sera were tested for IgA antibodies against human recombinant TGA. Significance (P < .05) of the correlation between TGA titer and age in these ponies was assessed using Pearson test (two tailed). In addition, to further illustrate tentative equine gluten-sensitive enteropathy and dermatitis, the clinical course in an 11-year-old Dutch Warmblood sport horse gelding has been described. The average TGA titer was 21.4 ± 13.6 AU/mL (range 2-65 AU/mL). There was a significant (P = .013) correlation (r = 0.389) between age and TGA titer in ponies. One of the 40 ponies (2.5%) showed an elevated TGA titer. An elevated TGA titer decreased after a gluten-free ration for 3 months in an 11-year-old Warmblood gelding with a tentative diagnosis of ISBD associated with full remission of the generalized skin reaction. To our best knowledge, this is the first study assessing TGA antibodies in sera from healthy non-gluten-free ponies and showing a correlation with age. The presented case could be the first one of a horse with a tentative diagnosis of gluten-sensitive enteropathy combined with dermatitis. Given the reported findings, this study warrants further investigations into gluten-sensitive enteropathy and dermatitis in individual horses affected with ISBD.
有人认为，麸质可能在马的炎症性小肠疾病（ISBD）中起作用。以前的研究表明，马的麸质敏感性肠病与血清中组织转谷氨酰胺酶（TGA）的 IgA 抗体之间存在关联。本研究旨在调查一组健康的非无麸质运动小马的 TGA IgA 抗体的流行率，并介绍一例疑似的马的麸质敏感性肠病和皮炎。从 40 匹健康的跳跃小马中采集血液样本。这些小马包括 12 匹母马、8 匹公马和 20 匹骟马，平均年龄为 9.0 ± 3.8 岁（±标准差；范围 3-19 岁）。检测血清中针对人重组 TGA 的 IgA 抗体。使用 Pearson 检验（双侧）评估这些小马中 TGA 效价与年龄之间相关性的显著性（P<.05）。此外，为了进一步说明疑似马的麸质敏感性肠病和皮炎，描述了一例 11 岁荷兰温血运动马骟的临床病程。平均 TGA 效价为 21.4 ± 13.6 AU/mL（范围 2-65 AU/mL）。在小马中，年龄与 TGA 效价之间存在显著相关性（P=.013）（r=0.389）。在一例 11 岁的温血骟马中，TGA 效价升高，该马疑似患有 ISBD，并伴有全身性皮肤反应的完全缓解，在无麸质饮食 3 个月后，TGA 效价降低。据我们所知，这是第一项评估健康无麸质小马血清中 TGA 抗体并显示与年龄相关的研究。该病例可能是首例疑似麸质敏感性肠病合并皮炎的马。鉴于报道的发现，本研究值得进一步研究个别患有 ISBD 的马的麸质敏感性肠病和皮炎。
