Karton E, Vakushina E, Seleskeridi V, Grigorenko M
1Federal State Budgetary Educational Institution of the Higher Education «A.I. Yevdokimov Moscow State University of Medicine and Dentistry» of the Ministry of Healthcare of the Russian Federation, Department of Orthodontics, Moscow, Russia.
2Federal State Budgetary Educational Institution of the Higher Education Stavropol State Medical University of the Ministry of Healthcare of the Russian Federation, Department of Orthopedic Dentistry, Russia.
Georgian Med News. 2020 Apr(301):68-73.
Aim of the study- improving the methods of prevention and hygiene of the oral mucosa of dental patients receiving high-dose toxic chemotherapy. 55 patients aged from 30 to 65 years of oncological profile with a combined dental pathology were taken for clinical observation. Patients were divided into 2 groups according to the applied methods of oral hygiene: in group 1, a standard hygienic technique was used; group 2 additionally used the hygiene and prophylactic agent "CITO-STOP", adapted for patients undergoing high-dose chemotherapy. Measurement and comparison of the amount of methotrexate in the oral fluid in both groups was carried out according to a single scheme. The measurement was carried out by high performance liquid chromatography immediately before the introduction of methotrexate, then after the start of infusion at the following time intervals: 1 hour, 2 hours, 4 hours, 6 hours, 8 hours, 16 hours, 24 hours, 48 hours, respectively. The study of Candidaalbicans on sensitivity to the author's hygiene and prophylactic agent "CITO-STOP" was carried out in both groups. Means "CITO-STOP" has a declaration of conformity of the Eurasian Economic Union and is approved for clinical use and sale on the territory of the Russian Federation (Patent for invention No. 2607931 dated January 11, 2017). Statistical processing of the results was carried out in both groups according to a single technique. In samples of oral fluid in patients using the optional "CITO-STOP" for oral hygiene, the amount of methotrexate is significantly reduced. The effect of the drug on the Candidaalbicans culture leads to damage to the exocular matrix and subsequent lysis of the Candidaalbicans culture. The developed and tested author's remedy "CITO-STOP" is an effective tool for the prevention and oral hygiene of dental cancer patients. This tool has analgesic, epithelizing and antifungal properties. The amount of methotrexate in the oral fluid after the use of high-dose chemotherapy with the use of the hygienic prophylactic "CITO-STOP" has been proven to decrease. "CYTO-STOP" has a pronounced fungicidal activity Patients of the second group who used the "CITO-STOP" foam for additional oral hygiene and the prevention of post-cytostatic stomatitis noted an improvement in the quality of life by reducing the pain symptom, eliminating bleeding of the mucous membrane and halitosis (halitosis).
研究目的——改进接受大剂量毒性化疗的牙科患者口腔黏膜的预防和卫生方法。选取55名年龄在30至65岁、患有肿瘤疾病且合并牙科病理问题的患者进行临床观察。根据口腔卫生应用方法将患者分为2组：第1组采用标准卫生技术；第2组额外使用专为接受大剂量化疗的患者适配的卫生预防剂“CITO - STOP”。按照单一方案对两组患者口腔液中甲氨蝶呤的含量进行测量和比较。在引入甲氨蝶呤之前、输液开始后的以下时间间隔（分别为1小时、2小时、4小时、6小时、8小时、16小时、24小时、48小时）立即通过高效液相色谱法进行测量。对两组患者的白色念珠菌进行对作者的卫生预防剂“CITO - STOP”敏感性的研究。“CITO - STOP”具有欧亚经济联盟的合格声明，并已获批准在俄罗斯联邦境内临床使用和销售（2017年1月11日发明专利权第2607931号）。两组均按照单一技术对结果进行统计处理。在使用可选的“CITO - STOP”进行口腔卫生的患者口腔液样本中，甲氨蝶呤的含量显著降低。该药物对白色念珠菌培养物的作用导致胞外基质受损，随后白色念珠菌培养物溶解。研发并测试的作者的药物“CITO - STOP”是牙科癌症患者预防和口腔卫生的有效工具。该工具具有止痛、促进上皮化和抗真菌特性。已证实使用卫生预防剂“CITO - STOP”进行大剂量化疗后口腔液中甲氨蝶呤的含量会降低。“CYTO - STOP”具有显著的杀真菌活性。使用“CITO - STOP”泡沫进行额外口腔卫生和预防细胞毒性后口腔炎的第二组患者指出，通过减轻疼痛症状、消除黏膜出血和口臭（口腔异味），生活质量得到改善。
