Zheng F, Zhai X L, Wang W J, Guo K P, Xiao C C, Ni Q C
Department of General Surgery, Shanghai Electric Power Hospital, Shanghai, 200050, China.
Department of Oncology, the Second Affiliated Hospital of Nantong University, Nantong 226001, China.
Zhonghua Yi Xue Za Zhi. 2020 Jun 9;100(22):1745-1749. doi: 10.3760/cma.j.cn112137-20190905-01975.
To investigate the expression and clinical significance of LRFN4 in colorectal cancer. A total of 210 cases of colorectal cancer tissues and 228 cases of corresponding surgical margin tissues were collected. Immunohistochemistry was employed to evaluate the expression of LRFN4 in colorectal cancer.The correlation between LRFN4 expression and clinicopathological features of colorectal cancer as well as patient outcome were analyzed. The positive rate of LRFN4 in colorectal cancer and in non-cancer was 55.24%(116/210), and 37.28% (85/228) , respectively.The expression of LRFN4 in colorectal cancer tissues was higher than that in non-cancer tissues(χ(2)=14.196, <0.001). High expression of LRFN4 was significantly correlated with tumor location(χ(2)=4.133,=0.042), T staging(χ(2)=6.494,=0.039), N staging(χ(2)=11.715,=0.008), TNM staging(χ(2)=13.398,=0.004), CEA (χ(2)=6.017, =0.049), but without gender, age, degree of differentiation, M staging(>0.05).The Kaplan-Meier survival curves indicated that high LRFN4 expression was associated with good survival (<0.05). In addition, Cox proportional hazards model showed that the high expression of LRFN4(=0.585, =0.018)was an independent risk factor for prognosis in patients with colorectal cancer. The expression of LRFN4 is up-regulated in colorectal cancer, which is significantly correlated with the clinicopathological features and prognosis. High expression of LRFN4 reduced the risk of death in patients with colorectal cancer.
探讨LRFN4在结直肠癌中的表达及临床意义。共收集210例结直肠癌组织及228例相应手术切缘组织。采用免疫组织化学法评估LRFN4在结直肠癌中的表达。分析LRFN4表达与结直肠癌临床病理特征及患者预后的相关性。LRFN4在结直肠癌和癌旁组织中的阳性率分别为55.24%（116/210）和37.28%（85/228）。结直肠癌组织中LRFN4的表达高于癌旁组织（χ(2)=14.196，P<0.001）。LRFN4高表达与肿瘤部位（χ(2)=4.133，P=0.042）、T分期（χ(2)=6.494，P=0.039）、N分期（χ(2)=11.715，P=0.008）、TNM分期（χ(2)=13.398，P=0.004）、CEA（χ(2)=6.017，P=0.049）显著相关，但与性别、年龄、分化程度、M分期无关（P>0.05）。Kaplan-Meier生存曲线表明，LRFN4高表达与良好的生存相关（P<0.05）。此外，Cox比例风险模型显示，LRFN4高表达（P=0.585，P=0.018）是结直肠癌患者预后的独立危险因素。LRFN4在结直肠癌中表达上调，与临床病理特征及预后显著相关。LRFN4高表达降低了结直肠癌患者的死亡风险。
