Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science.
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science.
J Atheroscler Thromb. 2021 Mar 1;28(3):283-292. doi: 10.5551/jat.55863. Epub 2020 Jun 14.
The relationship between central arterial stiffness and aging-related intracranial arteriopathy is not well investigated in the general population. In a population-based study, we investigated arterial stiffness in relation to intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia.
This study was a cross-sectional analysis on 1,123 subjects (aged 56.0±9.3 years, 37.9% men) of the population-based Shunyi study in China. Arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV). Intracranial atherosclerotic stenosis and intracranial arterial dolichoectasia were evaluated via brain magnetic resonance angiography. Multivariate regression models were constructed to investigate the association between baPWV and intracranial large artery diseases.
Increased baPWV was significantly associated with higher prevalence of intracranial atherosclerotic stenosis (odds ratio for the highest quartile of baPWV compared with the lowest quartile, 3.66 [95% confidence interval, 1.57- 8.54]), after adjustment for cardiovascular risk factors in multivariate analysis. BaPWV was not associated with the presence of basilar artery dolichoectasia and dilation of basilar artery and internal carotid artery. When the diameters of intracranial arteries were regarded as continuous variables, increased baPWV was inversely related to the internal carotid artery diameter in fully adjusted models (β±SE, -0.083±0.042, p = 0.047).
This population-based study demonstrates that arterial stiffness was more likely associated with intracranial stenotic arteriopathy other than intracranial dilative arteriopathy.
在一般人群中，关于中心动脉僵硬与衰老相关的颅内血管病变之间的关系尚未得到充分研究。在一项基于人群的研究中，我们调查了动脉僵硬与颅内动脉粥样硬化性狭窄和颅内动脉迂曲之间的关系。
本研究是对中国基于人群的顺义研究中 1123 名受试者（年龄 56.0±9.3 岁，37.9%为男性）的横断面分析。通过测量肱踝脉搏波速度（baPWV）评估动脉僵硬。通过脑磁共振血管造影评估颅内动脉粥样硬化性狭窄和颅内动脉迂曲。构建多元回归模型以研究 baPWV 与颅内大动脉疾病之间的关系。
在多元分析中，调整心血管危险因素后，baPWV 升高与颅内动脉粥样硬化性狭窄的患病率显著相关（baPWV 最高四分位与最低四分位相比的优势比为 3.66 [95%置信区间为 1.57-8.54]）。baPWV 与基底动脉迂曲和基底动脉及颈内动脉扩张无关。当将颅内动脉直径视为连续变量时，在完全调整的模型中，baPWV 升高与颈内动脉直径呈负相关（β±SE，-0.083±0.042，p=0.047）。
本基于人群的研究表明，动脉僵硬与颅内狭窄性血管病变的关系比颅内扩张性血管病变更密切。
