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高剂量局部用辣椒素在周围神经病变管理中的应用：叙述性综述与本地经验

The use of high dose topical capsaicin in the management of peripheral neuropathy: narrative review and local experience.

作者信息

Thomas Sarah E, Laycock Helen

机构信息

Chelsea and Westminster Hospital, London, UK.

Great Ormond Street Hospital, London, UK.

出版信息

Br J Pain. 2020 May;14(2):133-140. doi: 10.1177/2049463720914332. Epub 2020 Apr 15.

DOI:10.1177/2049463720914332
PMID:32537152
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7265596/
Abstract

Capsaicin, derived from the chilli pepper plant, is available in high concentration (8%) patches to provide topical therapy for neuropathic pain. Its analgesic effects relate to defunctionalisation and nerve terminal retraction of predominantly C fibres in the dermis and epidermis. Systematic reviews and meta-analysis support its use for the management of post-herpetic neuralgia and HIV neuropathy with some evidence for use in painful peripheral diabetic neuropathy. The article concludes with advice on the practicalities of running a topical 8% capsaicin clinic for peripheral neuropathic pain.

摘要

辣椒素源自辣椒植株，有高浓度（8%）的贴片制剂，可用于为神经性疼痛提供局部治疗。其镇痛作用与真皮和表皮中主要为C纤维的功能丧失及神经末梢回缩有关。系统评价和荟萃分析支持其用于治疗带状疱疹后神经痛和HIV相关性神经病变，并有一些证据表明其可用于治疗疼痛性糖尿病周围神经病变。文章最后给出了关于开设8%辣椒素局部治疗周围神经病变门诊的实用建议。

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Exp Ther Med. 2019 Aug;18(2):916-925. doi: 10.3892/etm.2019.7513. Epub 2019 Apr 19.
2
QAPSA: post-marketing surveillance of capsaicin 8% patch for long-term use in patients with peripheral neuropathic pain in France.QAPSA：法国一项针对辣椒素 8%贴剂长期使用治疗周围神经性疼痛患者的上市后监测研究
Curr Med Res Opin. 2019 Mar;35(3):417-426. doi: 10.1080/03007995.2018.1558850. Epub 2019 Jan 7.
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Drugs. 2018 Sep;78(14):1489-1500. doi: 10.1007/s40265-018-0982-7.
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Eur J Pain. 2018 May;22(5):941-950. doi: 10.1002/ejp.1180. Epub 2018 Feb 1.
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