Two cytotoxic squalene-derived polyethers from the Japanese red alga .

The red alga is known to produce and contain a rich diversity of secondary metabolites, such as domoic acid-related alkaloids and triterpene polyethers. Our investigation on red alga from Kagoshima coast, Japan, resulted in the isolation of two new triterpene polyethers, bandokorols A () and B (). The structures of these compounds were determined based on spectroscopic data such as infrared (FTIR), H-NMR, APT, H-H-COSY, HSQC, HMBC, NOESY and FAB mass spectrometry (HRFABMS). The anticancer potentials of these compounds were tested against adult T-cell leukaemia (ATL), S1T cells and their IC values are reported here.