来自红藻粗枝软骨藻的两种新的软骨藻酸异构体。

Two new isomers of domoic acid from a red alga, Chondria armata.

作者信息

Zaman L, Arakawa O, Shimosu A, Onoue Y, Nishio S, Shida Y, Noguchi T

机构信息

Laboratory of Marine Botany and Environmental Science, Faculty of Fisheries, Kagoshima University, Japan.

出版信息

Toxicon. 1997 Feb;35(2):205-12. doi: 10.1016/s0041-0101(96)00123-7.

DOI:10.1016/s0041-0101(96)00123-7

PMID:9080577

Abstract

Isodomoic acids G and H, two new isomers of the neurotoxin domoic acid, along with isodomoic acids A, B, E and F, were isolated from a red alga, Chondria armata, collected at the southern tip of Kyushu Island. The structures of two of these were deduced to be (E, E) and (Z, E) isomers of 2-carboxy-4-(5-carboxy-l-methyl-2-hexenylidene)-3-pyrro- lidineacetic acid, based on electrospray ionization mass and [1H]nuclear magnetic resonance spectral analyses including [1H-1H]correlation spectroscopy and nuclear Overhauser effect correlation spectroscopy.

摘要

从九州岛南端采集的红藻冈村软骨藻（Chondria armata）中分离出了异石房蛤毒素G和H，这两种新的神经毒素石房蛤毒素异构体，以及异石房蛤毒素A、B、E和F。基于电喷雾电离质谱和[1H]核磁共振光谱分析，包括[1H-1H]相关光谱和核Overhauser效应相关光谱，推断出其中两种的结构为2-羧基-4-(5-羧基-1-甲基-2-己烯叉基)-3-吡咯烷乙酸的(E, E)和(Z, E)异构体。