Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Nutr Metab Cardiovasc Dis. 2020 Jul 24;30(8):1389-1396. doi: 10.1016/j.numecd.2020.04.014. Epub 2020 Apr 24.
Although many observational studies have suggested that alcohol intake was associated with incident atrial fibrillation (AF), controversy remains. This study aimed to examine the causal association of alcohol intake with the risk of AF.
Two-sample Mendelian randomization (MR) analysis was performed to estimate the causal effects of alcohol consumption, alcohol dependence, or alcohol use disorder identification test (AUDIT) scores on AF. Summary data on single nucleotide polymorphisms (SNPs) associated with AF were obtained from a genome-wide association study (GWAS) with up to 1,030,836 participants. The fixed- and random-effect inverse-variance weighted (IVW) methods were used to calculate the overall causal effects. MR analysis revealed nonsignificant association of genetically predicted alcohol consumption with risk of AF using fixed- and random-effect IVW approaches (odds ratio (OR) [95% confidence interval (CI)] = 1.004 [0.796-1.266], P = 0.975; OR [95% CI] = 1.004 [0.766-1.315], P = 0.979). Genetically predicted alcohol dependence was also not causally associated with AF in the fixed- and random-effect IVW analyses (OR [95% CI] = 1.012 [0.978-1.048], P = 0.490; OR [95% CI] = 1.012 [0.991-1.034], P = 0.260). There was no significantly causal association between AUDIT and AF in the fixed- and random-effect IVW analyses (OR [95% CI] = 0.889 [0.433-1.822], P = 0.748; OR [95% CI] = 0.889 [0.309-2.555], P = 0.827). Sensitivity analyses indicated no evidence of pleiotropy and heterogeneity in statistical models.
This MR study did not find evidence of a causal association between alcohol intake and AF.
虽然许多观察性研究表明饮酒与房颤（AF）的发生有关，但仍存在争议。本研究旨在检验饮酒与 AF 风险之间的因果关系。
采用两样本孟德尔随机化（MR）分析来估计酒精摄入、酒精依赖或酒精使用障碍识别测试（AUDIT）评分与 AF 之间的因果关系。通过全基因组关联研究（GWAS）获得了与 AF 相关的单核苷酸多态性（SNP）的汇总数据，GWAS 纳入了多达 1,030,836 名参与者。使用固定效应和随机效应逆方差加权（IVW）方法计算整体因果效应。MR 分析显示，使用固定效应和随机效应 IVW 方法，遗传预测的酒精摄入量与 AF 风险之间无显著关联（比值比（OR）[95%置信区间（CI）]=1.004 [0.796-1.266]，P=0.975；OR [95% CI]=1.004 [0.766-1.315]，P=0.979）。固定效应和随机效应 IVW 分析也表明，遗传预测的酒精依赖与 AF 无因果关系（OR [95% CI]=1.012 [0.978-1.048]，P=0.490；OR [95% CI]=1.012 [0.991-1.034]，P=0.260）。在固定效应和随机效应 IVW 分析中，AUDIT 与 AF 之间也没有显著的因果关系（OR [95% CI]=0.889 [0.433-1.822]，P=0.748；OR [95% CI]=0.889 [0.309-2.555]，P=0.827）。敏感性分析表明，在统计模型中没有证据表明存在多效性和异质性。
本 MR 研究未发现饮酒与 AF 之间存在因果关系的证据。
