University of Western Ontario, London, Canada.
Parkwood Institute, Mental Health Care Building, Stn B, P.O. Box 5777, London, ON, N6A 4V2, Canada.
Arch Womens Ment Health. 2020 Oct;23(5):613-623. doi: 10.1007/s00737-020-01044-w. Epub 2020 Jun 16.
Antidepressants are the mainstay of drug treatment for moderate or severe postpartum depression. Knowledge of predictors of response could help optimize treatment and reduce the adverse consequences of postpartum depression. The purpose of this systematic review was to ascertain predictors of response or remission to antidepressant treatment in women with postpartum depression. The electronic databases of MEDLINE/PubMed, PsycINFO, CINAHL, Cochrane Database of Systematic Reviews, and Evidence-based Medicine Reviews were searched through December 2019. The search was limited to studies published in the English language. Reference lists of articles that met the inclusion criteria were also searched. We identified some predictors of response and remission that could potentially assist in the optimization of drug treatment of postpartum depression; however, caution is needed to apply these findings in clinical practice due to the heterogeneous nature of postpartum depression. The results of our review highlight the urgent need to identify predictors of response, non-response, or remission to antidepressants in women with postpartum depression.
抗抑郁药是治疗中度或重度产后抑郁症的主要药物。了解反应的预测因素可以帮助优化治疗，减少产后抑郁症的不良后果。本系统评价的目的是确定产后抑郁症女性对抗抑郁药物治疗反应或缓解的预测因素。通过 2019 年 12 月对 MEDLINE/PubMed、PsycINFO、CINAHL、Cochrane 系统评价数据库和循证医学评价的电子数据库进行了检索。检索仅限于发表英文的研究。还对符合纳入标准的文章的参考文献进行了检索。我们确定了一些可能有助于优化产后抑郁症药物治疗的反应和缓解的预测因素；然而，由于产后抑郁症的异质性，在临床实践中应用这些发现时需要谨慎。我们的综述结果强调了迫切需要确定产后抑郁症女性对抗抑郁药物反应、无反应或缓解的预测因素。
