遗传因素与憩室病风险-新证据。
Genetic Risk Factors for Diverticular Disease-Emerging Evidence.
机构信息
Division of Colorectal Surgery, Department of Surgery, University of Michigan, 2922 Taubman Canter, 1500 Medical Center Drive, Ann Arbor, MI, 48109, USA.
出版信息
J Gastrointest Surg. 2020 Oct;24(10):2314-2317. doi: 10.1007/s11605-020-04693-5. Epub 2020 Jun 15.
Abstract
Diverticular disease is traditionally understood as an environmental disease caused by diet and constipation. However, genes are increasing understood to play a role in pathogenesis. Twin studies suggest a substantial component of individual risk is due to heritable factors. Association of diverticular disease with other traits suggests an underlying biological mechanism and recently genome-wide association studies have described the genetic architecture underlying this complex phenotype. These studies suggest a new paradigm for understanding this common surgical disease.
摘要
憩室病传统上被认为是一种由饮食和便秘引起的环境疾病。然而，基因在发病机制中所起的作用也越来越被人们所理解。双胞胎研究表明，个体风险的很大一部分归因于遗传因素。憩室病与其他特征的关联表明存在潜在的生物学机制，最近的全基因组关联研究描述了这种复杂表型的遗传结构。这些研究为理解这种常见的外科疾病提供了一个新的范例。
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